Critical instrument design considerations

As described above, performance testing is an important consideration in the design of a critical instrument loop. Components of the system must be selected for ease of testing, as well as for their ruggedness and reliability. 

MTP readers are critical to kinase assay development and design. These instruments are available in a large variety of choices and it is not our intention to bias the reader toward any system. The choice often depends on factors such as budget, existing HTS infrastructure, throughput needs, and project-specific scientific considerations. Plate readers are based on many principles, including ... 

Application of the HRF increases the transparency of delineation of the relative degrees of nncertainty associated with various options for considraation in assessment of risk for impacted populations. HRFs are also instrumental in acquiring transparency on critical data gaps that will further reduce uncertainty. They force distinction of choices made on the basis of science policy versns those that are science jndgment related, inclnding reliance on default, based on the erroneous premise that it is always health-protective (Meek and Doull 2009). They focus on early events in a toxicity pathway through relation of early perturbations to apical endpoints in frameworks designed to systematically address (a) consideration of key events in modes of action and (b) their snbseqnent implications for dose-response in risk assessment [see, for example. Meek (2008)]. 

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