Cosolvency oral liquid formulations

Suspensions are two-phase systems consisting of a finely divided solid dispersed in a liquid, solid, or a gas (Table 6). They are appropriate when the drug to be incorporated is not sufficiently soluble in an ordinary solvent or cosolvent system. They are used orally and topically. Examples of compounded suspensions include pediatric oral liquids where a commercial pediatric dosage form is not available. Commercial tablets and capsules are formulated into a vehicle and can be individually flavored to the patient s preference. 

S-SNEDDS complement the liquid SNEDDS and overcome the limitations that include poor stability and portability, plausible interactions of the formulation component with the capsule shell, and evaporation of the cosolvent leading to precipitation of the drug associated with the liquid SNEDDS. Reduction in the volume of administration, due to the solid state of S-SNEDDS, enhances precise dosing. Various techniques, such as adsorption on the inert carriers, spray drying, extrusion—spheronization, and melt granulation, have been explored for the formulation of S-SNEDDS (Tan et al., 2013). S-SNEDDS utilized for enhancing the oral bioavaUability of drug candidates are listed in Table 4.4. 

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