Corticosterone methyloxidase

I Corticosterone methyloxidase I, II corticosterone methyloxidase II, 18-OH-THA 18-hydroxytetrahydro-l 1-dehy-drocorticosterone, Bs the sum of tetrahydrometabolites of corticosterone, Fs the sum of the tetrahydrometabolites of cortisol... 

Hydroxysteroid dehydrogenase (corticosterone methyloxidase deficiency) Hypotension Restricted to zona glomerulosa sole aldosterone defect hyponatremia, hyperkalemia, increased renin Mineralocorticoid replacement without glucocorticoid replacement... 

Corticosterone methyloxidase deficiency type I, or type II occasional CAH Chimeric enzymes causing glucocorticoid-remediable aldosteronism occasional CAH Mineralocorticoid excess syndromes, glucocorticoid, and sex hormone deficiencies association with increased risk of prostate cancer and benign prostatic hypertrophy occasional CAH... 

The issues of congenital adrenal h5 erplasia and Types I and II corticosterone methyloxidase deficiency in individuals with attenuated P450 11B2 activity have already been mentioned. The other issue also mentioned is elevated aldosterone. Several studies have reported an association between polymorphisms and essential h5 erten-sion, although the measurements of aldosterone excretion are still lacking in some studies . Other studies show association of the -344C allele with increased left ventricular size . The hypertension association has been seen in several studies - - but not in a Japanese... 

Pascoe, L., K.M. Curnow, L. Slutsker, A. Rosier, and PC. White (1992). Mutations in the human CYPUB2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Proc. Natl. Acad. Sci. USA 89, 4996-5000. 

CYP11B2 Corticosterone methyloxidase deficiency type I, or type II occasional CAH... 

B2 catalyzes the 1 lyff-hydroxylation of 11-deoxycorticosterone followed by 18-hydroxylation and 2-electron oxidation of the 18-alcohol to an aldehyde (Figs. 9.12 and 9.23). Changes in the gene can lead to corticosterone methyloxidase deficiency and hyperaldosteronism [47, 1980, 2055, 2056]. In the older literature, this P450 is sometimes termed P450 j . ... 

The crossovers between P450s llBl and 11B2 yield inactive P450 11B2, as well as P450 llBl [2016, 2017, 2099, 2100]. Other variants in CYP11B2 were associated with corticosterone methyloxidase I and II deficiency [2055, 2056,... 

White PC (1992) Mutations in the human CL-P11B2 (aldosteronesynthase) gene causing corticosterone methyloxidase 11 deficiency. Proc Natl 2068. Acad Sci U S A 89 4996-5000... 

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