Corticosteroids lupus nephritis

Darmawan J, Zhao DB, Soorosh GS, Chen S-L, Haq SY. Sustained remission in DMARD-refractory Lupus nephritis treated with step-down bridge comhination therapy of five immunosuppressants without corticosteroids a six years international study in Asia -WHO-ILAR COPCORD Stage 11 treatment. APLAR J Rheumatol 2007 10 in press. 

Evidence supporting the use of cyclophosphamide in lupus nephritis has been collected over the last several decades. Controlled clinical trials have shown that cyclophosphamide improved the longterm outcomes in lupus nephritis. " Based on controlled trials, combination prednisone and cyclophosphamide has become standard treatment for focal and diffuse proliferative lupus nephritis (WHO class III/IV) and is superior to prednisone alone. There are no studies examining cyclophosphamide in earlier stages of nephritis (WHO class II/III), and therefore, corticosteroids remain the treatment of... 

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