Corticosteroids fluorometholone

Figure 12-1 Aqueous humor steroid activity using the glucocorticoid receptor assay after administration of topical unlabeled fluorometholone 0.1% and fluorometholone acetate 0.1% in rabbits. (Adapted from Polansky JR. Basic pharmacology of corticosteroids. Curr Top Ocul Inflam 1993 1 19.)...

Figure 12-3 Weekly intraocular pressure responses of eyes treated with medrysone 1%, fluorometholone 0.1%, and dexamethasone phosphate 0.1%. Each point represents a mean value (mm Hg) of 12 eyes. (Reprinted with permission from Mindel JS, Tovitian HO, Smith H, et al. Comparative ocular pressure elevations of topical corticosteroids. Arch Ophthalmol 1980 98 1578. Copyright 1980, American Medical Association.)...

Corticosteroid-induced ocular hypertension appears to relate not only to the individual patient but to the specific steroid used. In general, dexamethasone 0.1%, betamethasone 0.1%, and prednisolone acetate appear more likely to induce significant lOP elevations than do fluorometholone alcohol and medrysone. Clinical studies with rimexolone and LE indicate that they have less potential to elevate lOP than does dexamethasone phosphate or prednisolone acetate. 

Fluorometholone, a corticosteroid with ophthalmic antiinflammatory properties (instill 2 drops in conjunctival sac), is used in inflammatory and allergic conditions of cornea, conjunctiva, sclera, and anterior nvea. 

Prolonged use of 0.1% fluorometholone was beneficial for the prevention of rejection after PKP. Because no adverse consequences were noted, it is recommended to continue using low-dose corticosteroids, even in non-high-risk cases. 

---