Coronary artery bypass graft CABG -patch trial

CABG PATCH = Coronary Artery Bypass Graft (CABG) Patch Trial. 

Survival curves in MADIT II did not separate until 9 months after enrollment, raising the question of when an ICD should be implanted after MI or revascularization. Two notable negative primary prevention trials may answer this question. The Coronary Artery Bypass Graft Patch (CABG-Patch) Trial evaluated whether primary prevention with ICD at the time of surgical revascularization in patients with EF < 35% and a positive SAECG would reduce total mortality [33]. At 32 months follow-up, no difference was found, suggesting that there is no additional benefit to ICD therapy at the time of revascularization. 

Arguably, ICDs for primary prevention has greater benefit for the entire population than ICDs for secondary prevention. Several key primary prevention trials have been completed M IT, MUSTT, CABG-Patch (Coronary Artery Bypass Graft surgery), MADIT II, DINAMIT (Defibrillator in Acute Myocardial Infarction Trial), DEFINITE (Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation), SCD-HeFT, CAT (CArdiomyopathy Trial), and AMIOVERT (AMIOdarone VERsus implanv cardioverTer-defibrillator) trials (Table 14.4) (54,119,172-174). 

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