Corneal keratan sulfate

Tai GH, Nieduszynski lA, Fullwood NJ, Huckerby TN. Human corneal keratan sulfates. J. Biol. Chem. 1997 272(45) 28227— 28231. 

Oeben M, Keller R, Stuhlsatz HW, Greihng H. Constant and variable domains of different disaccharide structure in corneal keratan sulfate chains. Biochem. J. 1987 248(1) 85—93. 

Akama TO, Misra AK, Hindsgaul O, Fukuda MN. Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate. J. Biol. Chem. 2002 277(45) 42505-42513. Akama TO, Nakayama J, Nishida K, Hiraoka N, Suzuki M, McAuliffe J, Hindsgaul O, Fukuda M, Fukuda MN. Human comeal GlcNAc 6-O-sulfotransferase and mouse intestinal Glc-NAc 6-O-sulfotransferase both produce keratan sulfate. J. Biol. Chem. 2001 276(19) 16271-16278. 

Keratan p-Gal/ -(l )-p-GalNAc/ -(l->3). Oligosaccharide chains (20-50 residues) derived from this polymer form part of biantennary N-linked glycoproteins (keratin sulfate type I, such as corneal keratan sulfate) and shorter stretches, fucosylated, as part of O-linked glycoproteins (keratin sulfate type II, such as... 

Skeletal keratan sulfate and corneal keratan sulfate chains are attached to core protein through O-linked oligosaccharides [29] and N-linked oligosaccharides [30,31] respectively, identical to O-linked and N-linked oligosaccharides of the general class of glycoproteins. 

Blochberger TC, Vergnes JP, Hempel J, Hassell JR. cDNA to chick lumican (corneal keratan sulfate proteoglycan) reveals homology to the small interstitial proteoglycan gene family and expression in muscle and intestine. J Biol Chem 1992 267 347-352. 

Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW. Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan. Invest Ophthalmol Vis Sci 1997 38 1159-1167. 

Corpuz LM, Funderburgh JL, Funderburgh ML, Bottomley GW, Prakash S, Conrad GW. Molecular cloning and tissue distribution of keratocan. Bovine corneal keratan sulfate proteoglycan 37A. J Biol Chem 1996 271 9759-9763. 

Corneal keratan sulfate is apparently unique among the glycosamino-glycans in its glycopeptide linkage in that the glycopeptide structure somewhat represents that which occurs in many glycoproteins (XIII)... 

Tai, G.-H., T.N. Huckerby, and LA. Nieduszynski. 1996. Multiple non-reducing chain termini isolated from bovine corneal keratan sulfates. J. Biol Chem. 271 23535-23546. 

Funderburgh, J.L., B. Caterson, and G.W. Conrad. 1987. Distribution of proteoglycans anti-genically related to corneal keratan sulfate proteoglycan. J. Biol Chem. 262 11634-11640. 

Funderburgh, J.L., P.R. Stenzel-Johnson, and J.W. Chandler. 1983. Monoclonal antibodies to rabbit corneal keratan sulfate proteoglycan. Curr. Eye Res. 2 769 775. 

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