Copper-catalyzed cross-dehydrogenative

Scheme 9.1 Copper-catalyzed cross-dehydrogenative coupling.

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles 49 with cycHc ethers 50 have been developed under mild conditions (130L4600). Notably, the 2-thiazolyl acetals, known as the masked 2-thiazolecarboxaldehydes, could be successfully obtained by this CDC reaction. 

Copper-Catalyzed Cross-Dehydrogenative-Coupling Reactions... 

Copper-catalyzed dehydrogenative cross-coupling reactions of (benzo) thiazoles with cychc ethers 106 to give the products 107 have been developed by Jiang and Chen (Scheme 51) (20120L4950, 20130L4600). A radical pathway was proposed for the reaction with cyclic ethers initiated... 

Over the last decade, the copper-mediated or copper-catalyzed C-H functionalization has been developed rapidly and greatly by significant efforts of many researchers, and cheap and abundant copper salts now can replace, to some extent, precedented noble transition metal catalysts such as Pd, Rh, and Ru. Moreover, some unique features of copper salts and complexes are observed. The intermolecular dehydrogenative cross-couplings mentioned in this chapter are such good examples, and they are otherwise challenging even under known noble transition metal catalysis. However, there is still a large room for further... 

SCHEME 7. 26 Copper-catalyzed oxidative cross-dehydrogenative-coupling of 3-ketoesters or 2-carbonyl-substituted phenols with ethers. 

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