Copper amine azide

Copper amine azide Copper tetramine nitrate Crotonaldehyde, stabilized Cyanogen bromide Cyanuric triazide... 

Copper amine azide Cu(NH3)2(N3)2 Dark green crystals explodes when heated to 105°C... 

Cuprates with Organic Cations. Copper (II) Azide, Cu(N3)2, dissolves more or less easily in many water-sol azides to form normal addn compds, called cuprates. The presence of cuprates can be detected by the blackening produced in water by pptn of Cu(N3)2. The water-sol cuprates are good conductors of electricity. Because of their N content, they are more expl than the corresponding nonelectrolytes. Compds with org amines as cations are described by Cirulis Straumanis (Ref 1). See Ref 2... 

Click reactions are an attractive means to synthesize SCNPs due to their high efficiency, high functional group tolerance, and mild reaction conditions. Copper-mediated azide-allgme cycloaddition, thiol-ene addition, thiol-yne addition, and amine-isocyanate addition" click reactions have been used to synthesize cross-links and form SCNPs. 

The functional groups from the starting monomers may be further modified either by click chemistry, such as thiol-ene, epoxy-amine reaction and copper catalyzed azide-alkyne cycloaddition. Authors also applied the Passerini synthesis pathway to a mixture of the three initial monomers to obtain a combined photodegradable polymer with triple functionality (P4) (Scheme 4). Reproduced with permission. Copyright 2014, American Chemical Society [3]. The photocleavable character may be determined by UV-Vis and gel permeation chromatography (GPC) techniques, when the polymers cleave into the corresponding ortho-nitrosobenzaldehydes and carboxylic acids. 

Polymers symthesized via ATRP can be easily modified, generally by substitution of the bromide end group [24]. For example, substitution with an azide opens the route for copper-catalyzed azide-aUcyne cycloaddition to yield a functional triazole or reduction to yield an amine that is amenable to further modification. As a recent example, Boyer et al. presented a straightforward method for the... 

In recent years, activated esters have become increasingly important in polymer chemistry therefore, it is not surprising that they are also represented in the field of surface modification. In one example, Lin et al. used silica oxide-coated Fc304, where amine functionalities could be attached simply by adding 3-aminopropyltrimethoxysilane (Scheme 23) [44]. The amine was introduced by a disuccinimide, whereby one succinimide reacted with the surface-bonded amine and the other remained accessible for subsequent reaction with 3-azidopropane amine. As described before, the introduced azide could then be used for copper-catalyzed azide-alkyne Huisgen cycloaddition to obtain sugar-coated iron nanoparticles. 

After its discovery in 2002, the copper-catalysed azide-allg ne dipolar cycloaddition (CuAAC) click reaction has found widespread application in glycoscience due to its broad tolerance of functional groups, offering high specificity and yield. It has found application in glycoproteins synthesis as well, for instance, in the transformation of the amine sidechain of lysine into an azide by treatment with imidazole-1-sulfonyl azide for subsequent CuAAC modification. Such methodology... 

Copper-catalyzed azide-alkyne cycloaddition has been used to couple the phenazine luminescent probe and an Af,Af-bis(2-picolyl)amine moiety in a 75% yield by using copper acetate (0.01 mol%) and sodium ascorbate in CH3CN/H2O (10 1) [94]. The cycloaddition of l,3-diethynyl-6-fluoroisoquinohne with 1-(2-azidoethyl)pyrrohdine has been applied to the synthesis of a soluble click fluorescent chemosensor (Scheme 3.5). The molecule displays good sensitivity toward heavy and transition metal ions such as Fe ", or Cu in water at pH 7.0 [95]. 

The synthesis and mechanism of formation of a triazene from an arenediazonium ion and an amine with one or two aliphatic substituents (see Scheme 13-1, R = alkyl, R = H or alkyl) will be discussed in Section 13.2. Here we will briefly mention Dimroth s method (1903, 1905 a) for synthesis of wholly aliphatic triazenes (Scheme 13-6, R and R = alkyl). Dimroth obtained these by the action of Grignard reagents on alkyl azides followed by isolation via copper(i) salts. The Grignard method can also be applied for the synthesis of triazenes with an aromatic substituent by using an aryl azide. 

The direct, stereoselective conversion of alkynes to A-sulfonylazetidin-2-imines 16 by the initial reaction of copper(l) acetylides with sulfonyl azides, followed, in situ, by the formal [2+2] cycloaddition of a postulated A-sulfonylketenimine intermediate with a range of imines has been described <06AG(E)3157>. The synthesis of A-alkylated 2-substituted azetidin-3-ones 17 based on a tandem nucleophilic substitution followed by intramolecular Michael reaction of primary amines with alkyl 5-bromo-4-oxopent-2-enoates has been... 

Another approach for the synthesis of networks relies on the polycondensation of multifunctionalized polyesters with the appropriate multifunctionalized agent, provided that one of the partner is at least tri-functionalized. Toward this end, several reaction have been reported, such as the Michael addition of amines onto acrylates [184], the coupling of ketones and oxyamines [185], the click copper(II)-catalyzed azide-alkyne cycloaddition [186], and esterification reactions [25, 159, 187]. Interestingly, if esterification reactions are used, the crosslinks are then degradable. 

Aminoefnanui-bii[cu)ipcf(i]/ diulidt], Ethan d-amine di (cupric azide) or Monoethanol ami no-tetrazido-copper. [(N.) Cu — H. N CH.-CHa OH-Cu(Ns)2], dk grn crysrs explg ca 186° or when thrown on a preheated metal block. It was obtained in a impure state and in small yield from Cu diazide and amino-... 

Cirulis (Ref 13) found that LA loaded into copper caps can form copper azide if moisture is present. Hydrazine and hydroxyl amine reduce Cu(Ns)2 to white, cuprous azide, CuN,... 

Metal nitrene complexes were used in a number of C-H amination reactions (recent reviews [358, 359]). Copper ketiminate complexes react with azides to nitrene complexes, which were isolated [360]. (p-Ketiminate)copper(I) complex 262 (2.5 mol%) serves therefore as an efficient catalyst for the intermolecular C-H amination of alkylarenes, cycloalkanes, or benzaldehydes 260 using adamantyl azide 261 as the nitrogen source ig. 68) [361]. The corresponding adamantyl amines or amides 263 were isolated in 80-93% yield. Copper complex 262 forms initially a dinuclear bridged complex with 261. From this a copper nitrene complex is generated by elimination of nitrogen, which mediates the hydrogen abstraction from 260. 

The cycloaddition of ethoxycarbonyl azide to racemic O-acetyl cyanohydrin 21 was performed either at 40 °C in acetone or at room temperature and without solvent in the presence of a metal salt (zinc(II) acetate, nickel chloride or copper(I) cyanide) as catalyst54. The required dihydro-triazole 22 (isolated from the 2 1 mixture of regioisomers) was directly converted to the jS-acetoxy amine via migration of the endo-acetoxy group. The Ivans relationship of the hydrogen atoms at C-5 and C-6 was deduced from ll NMR. 

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