Hill, Archibald

Hill, Archibald Vivian (1886-1977) British Physiologist Archibald Vivian Hill was born in Bristol on September 26, 1886. After an early education at Blundell s School, Tiverton, he entered Trinity College, Cambridge, with scholarships. He studied mathematics but was urged to go into physiology by one of his teachers, Walter Morley Fletcher. 

Archibald Hill demonstrated in 1913, well before any knowledge about the molecular organization of Hb existed, that the 02-binding behavior of Hb could be described by Equation (A15.12). If a value of 2.8 is taken for Equation (A15.12) fits the experimentally observed 02-binding curve for Hb very well (Figure A15.4). If the binding of O2 to Hb were an all-or-none phenomenon. 

Cooperative binding of oxygen by hemoglobin was first analyzed by Archibald Hill in 1910. From this work came a general approach to the study of cooperative ligand binding to multisubunit proteins. 

Archibald V. Hill and Otto F. Meyerhof Physiology/Medicine Chemistry of muscle contraction... 

Muscle anaerobic glycolysis yields lactate - Sir Frederick Gowland Hopkins (UK, shared Nobel Prize, Medicine, 1929, growth stimulating vitamins) Sir Archibald Hill (UK) ... 

Otto Meyerhof (Germany) (Nobel Prize, Medicine, 1922, aerobic glycolysis processes) Otto Meyerhof (glycolytic intermediates) (Germany, Nobel Prize, Physiology/ Medicine, 1922 with Archibald Hill (UK), metabolism)... 

Having lived under the path of air attacks on London in the First World War and having seen the horrific fireball of a bomb-carrying Zeppelin shot down in flames, Yardley became a pacifist. In a letter to Archibald V. Hill,35 she expanded on her beliefs ... 

Katz, B. (1978). Archibald Vivian Hill, 26 September 1886—3 June 1977. Biographical Memoirs of Fellows of the Royal Society 24 71-149. 

A useful way of quantitatively describing cooperative binding processes such as that for hemoglobin was developed by Archibald Hill in 1913. Consider the hypothetical equilibrium for a protein X binding a ligand S ... 

In 1910 Archibald Hill (4) derived an equation similar to Equation 9.4 to describe the hemoglobin 0, sigmoidal curve of Y versus [L] plots. Hill assumed that a protein has n... 

In 1909 Archibald V. Hill (Nobel Prize, 1922) proposed that the binding reaction between hemoglobin and O2 could be described by a reaction of molecularity n -f 1 ... 

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