Convection enhanced delivery

G. Popped, R. Goldbrunner, F.J. Gildehaus, F.W. Kreth, P. Tanner, M. Holtmannspotter, J.C. Tonn, K. Tatsch, 0-(2-[ F]fluoroethyl)-L-tyrosine PET for monitoring the effects of convection-enhanced delivery of paclitaxel in patients with recurrent glioblastoma, Eur. J. Nucl. Med. Mol. Imaging 32(9) (2005) 1018-1025. 

Chen, M.Y., Lonser, R.R., Morrison, P.F., Govemale, L.S. and Oldfield, E.H. (1999) Variables affecting convection-enhanced delivery to the striatum a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time. J. Neurosurg., 90, 315-320. 

Nguyen, J. B. et al. (2001). Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain. Neuroreport 12(9), 1961-1964. 

MakCay, A. J., Deen, D. F., and Szoka, F. C., Jr. (2005), Distribution in brain of liposomes after convection enhanced delivery modulation by particle charge, particle diameter, and presence of steric coating, Brain Res., 1035,139-153. 

Mamot, C., Nguyen, J. B., Pourdehnad, M., Hadaczek, P, Saito, R., Bringas, J. R., Drummond, D. C., Park, J. W., and Bankiewicz, K. S. (2004), Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery, J. Neuro-Oncol., 68,1-9. 

Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci U.S.A. 1994 91 207 80. 

Cunningham J, Oiwa Y, Nagy D, Podsakoff G, Colosi P, Bankiewicz KS (2000) Distribution of AAV-TK following intracranial convection-enhanced delivery into rats. Cell Transplant 9 585-594. 

Lidar Z, Mardor Y, Jonas T, Pfeffer R, Faibel M, Nass D, Hadani M, Ram Z. Convection-enhanced delivery of pacli-taxel for the treatment of recurrent malignant glioma a Phase I/II clinical study. J Neurosurg 2004 100 472-479. 

Vogelbaum MA, Sampson JH, Kunwar S et al. (2007) Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant ghomas phase 1 study of final safety results. Neurosurgery 61 1031-1037... 

Patel S et al. Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma initial experience in 51 patients. Neurosurgery 2005 56 1243-1253. 

Kioi M, Husain SR, Croteau D, Kunwar S, Puri RK. Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant gUoma therapy. Technol Cancer Res Treat 2006 5 239 250. 

Vogelbaum MA. Convection enhanced delivery for treating brain tumors and selected neurological disorders symposium review. J Neurooncol 2001 83 97-109. 

Saito, R., Krauze, M., Bringas, J., Nohle, C., McKnight, T., Jackson, P., et al. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate hrain. Exp. Neurol. 196, 381-389 (2005)... 

Bankiewicz, K.S., Eberling, J.L., Kohutnicka, M., et al Convection-enhanced delivery of AAV vector in parkinsonian monkeys in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp. Neurol. 164, 2-14 (2000). doi 10.1006/exnr.2000.7408... 

A number of carboranyl porphyrins have been obtained on the basis of the natural porphyrin derivatives, such as deuteroporphyrin IX and hematoporphyrin IX, and two of than, VCDP and BOPP (Figure 9.12), have been extensively studied in animals. BOPP was reported to have a tumor-normal brain ratio from 13 1 to 400 1 for different glioma models [117,118]. High boron levels in tumor (>60 pg °B/g tumor) were achieved in these animal studies. However, data obtained from a human Phase I clinical trial showed that under intravenous injection BOPP does not deliver therapeutic concentrations of boron to the tumors of glioblastoma patients, and dose escalation is prevented by the toxicity of this compound. Nevertheless, BOPP has shown some promise as an effective PDT photosensitizer [119-121]. More recently, it was demonstrated that convection-enhanced delivery of BOPP significantly enhances the boron concentration in tumors and produces very favorable tumor-brain and tumor-blood ratios [122]. 

Yang, W. Barth, R. R Wu, G. Huo, T. Tjarks, W. Ciesielski, M. Fenstermaker, R. A. et al. Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. J. Neuro-oncol. 2009, 95, 355-365. 

Allard, E., Passirani, C., and Benoit, J.P. 2009. Convection-enhanced delivery of nanocarriers for the treatment of brain tumors. Biomaterials 30 2302-18. 

---