Controlled-release tablets extract

TABLE 2 Composite Assay Data of Controlled-release Tablets Using Various Solidhandling and Extraction Techniques... 

FIGURE 6 HPLC chromatogram of an extract of a controlled-release tablet with one API showing the extraction efficiency between whole tablets by sonication and crushed tablets by shaking and sonication. 

This case study illustrates the SP method development of an assay method for a controlled-release analgesic tablet with a single API. Certain considerations were taken into account. First, the analyte within the tablet matrice core had to be extracted quantitatively. Second, the analyte was diluted into a final solution that was compatible with the HPLC mobile phase. Third, short SP time was required (i.e., 30 min) to maximize productivity of the work scheme for processing a large number of samples. 

Gavini E, Alamanni MC, Cossu M, Giunchedi P. Tabletted microspheres containing Cynara scoly-mus (var. Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices. J Microencapsul. 2005 22(5) 487—499. 

Extracted from the stem of different Commiphora spp.—C. myrrha (Nees) Engl., C. habessinica (O. Berg) Engl, C. wightii (Arn.) Bhandari—Burseraceae family, myrrh oleo gum resin has been known since ancient times due to its medicinal properties [397], In the drug industry, myrrh oleo gum resin may be used as directly compressible tablet excipient and release retardant [398] and as binder, release retardant and mucoadhesive for the preparation and evaluation of controlled release bioadhesive matrix tablets of domperidone [399]. 

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