Control Genetic Association Studies

Hung RJ, Brennan P, Malaveille C et al. Using hierarchical modeling in genetic association studies with multiple markers application to a case-control study of bladder cancer. Cancer Epidemiol Biomarkers Prev 2004 13 1013—1021. 

Silverman EK, Palmer LJ. Case-control association studies for the genetics of complex respiratory diseases. Am J Respir Cell Mol Biol 2000 22 645-648. 

One major concern of the association study is that spurious associations may occur if the genetic background in cases is different from that in controls. Genetic heterogeneity in a population can be a result of population structure and recent admixture. In this chapter, we review the problem of population structure, demonstrate how that structure affects association study, and discuss solutions to this problem. 

Clayton, D.G., Watkerr, N.M., Smyth, Deborah., etal. (2005) Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat. Genet. 37,1243-1246. 

Sacco, R., Papaleo, V., Hager, J., Rousseau, F., Moessner, R., Militerni, R., Bravaccio, P., Trillo, S., Schneider, C., Melmed, R., Elia, M., Curatolo, P., et al. (2007). Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes TPH2 and GLO 1. BMC Med. Genet. 8,11. 

Review of association studies of psychiatric disorders are restricted to family-based studies. However, all of the existing studies in the neuropsychiatric pharmaco-genetic literature have used the case-control design. Although the studies may provide useful leads for followup work, this weakness of the pharmacogenetic research performed to date needs to be acknowledged. 

Analogous mechanistic studies of the formation of zeolite minerals have been reported. Kossowskaya (51), in this volume, considers the genetic associations of sedimentary zeolites and the dominant factors controlling their process of formation. An especially lucid and concise presentation of the mechanism of formation of sedimentary zeolites under low temperature conditions is given by Mariner and Surdam (52). In studies on the formation of zeolites in saline alkaline lakes, they show differential... 

Zhao X, Shi Y, Tang J, Tang R, Yu L, et al. 2004. A case control and family based association study of the neuregulin 1 gene and schizophrenia. J Med Genet 41 31-34. 

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