Contrast agents magnetic resonance angiography

Miihler, A. (1998) The future of contrast-enhanced magnetic resonance angiography are blood pool agents needed Investigative Radiology, 33, 709-714. 

Both chelates have been launched as extracellular contrast agents using doses up to 3 mmol/kg body weight. Both can be formulated as 1.0 molar aqueous solutions with acceptable viscosity (Table 2). These highly concentrated agents are useful in fast dynamic studies such as brain perfusion and fast magnetic resonance angiography (MRA). 

Rosen BR, Belliveau JW, Vevea JM et al (1990) Perfusion imaging with NMR contrast agents. Magn Reson Med 14 249-265 Rother J, Wentz KU, Rautenberg W et al (1993) Magnetic resonance angiography in vertebrobasilar ischemia. Stroke 24 1310-1315... 

Tyekl, Z., Dunham, S.U., Midelfort, K., etal. (2007) Structural, kinetic, and thermodynamic characterization of the interconverting isomers of MS-325, a gadohnium(III)-based magnetic resonance angiography contrast agent. Inorganic Chemistry, 46, 6621-6631. 

Vasovist is the tradename of a Gd(III) complex which was the first intravascular contrast agent (see Box 4.3) approved in the EU for use in magnetic resonance angiography. Interactions between the lipophilic domain of the contrast agent and human serum albumin allow Vasovist to bind reversibly to the protein. Vasovist has the formula... 

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