Contraceptive, injectable Steroidal

Long-acting activity of injectable contraceptives can be accompHshed via a number of different approaches. Steroid activity can be extended over a... 

Gao, Z. Crowley, W.R. Shukla, A.J. Johnson, J.R. Reger, F. Controlled release of contraceptive steroids from biodegradable and injectable gel formulations in vivo evaluation. Pharm. Res. 1995, 12, 864—868. 

The stability of oils is very important in pharmaceuticals since nonpolar drugs (for example, contraceptive steroids and neuroleptic tranquillisers) are often formulated in oily injection vehicles for intramuscular or depot injection. Injections of this type can be given, for example, once a month, and the drug exerts its pharmacological effect as it leaches out of the injection site into the bloodstream. Oils used as injection vehicles include arachis oil, from the peanut plant, olive oil, castor oil and ethyl oleate, the ethyl ester of the 18-carbon fatty acid oleic acid (Figure 8.16). 

Steroid hormones provide long-term contraception when injected or implanted into the skin. The most commonly used steroids for... 

Dhanarajn MD, Jayaknmar R, Vamsadhara C. Infinence of manufacturing parameters on development of contraceptive steroid loaded injectable microspheres. Chemical and Pharmaceutical Bulletin. Angnst 2004 52(8) 976-979. PnbMed PMID 15304994. 

Dhanarajn MD, Rajkannan R, Selvaraj D, Jayaknmar R, Vamsadhara C. Biodegradation and biocompatibility of contraceptive-steroid-loaded poly (DL-lactide-co-glycoUde) injectable microspheres In vitro and in vivo stndy. Contraception. Angnst 2006 74(2) 148—156. PubMed PMID 16860053. 

M. Dasaratha Dhanaraju, D. Gopinath, M. Rafiuddin Ahmed, R. Jayakumar, and C. Vamsadhara, Characterization of polymeric poly(e-caprolactone) injectable implant delivery system for the controlled delivery of contraceptive steroids, / Biomed. Mater. Res. A, 76A(1), 63-72, 2006. 

Controlled release of contraceptive steroids from biodegradable and injectable gel formulations in vivo evaluation. Pharm. Res., 12, 864-868. 

Half-year-duration erodible systems, which are injectable, for systemic delivery of a progestational steroid for contraception (15). 

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