Continuous improvement usage rate

This chapter also demonstrates that the operation of batch extractive distillation can be improved by allowing the reflux ratio and the continuous entrainer feed rate to be varied with time. The simulation results of the IPA dehydration system demonstrate that batch time and entrainer usage can be reduced by including two temperature control loops to manipulate the reflux ratio and the entrainer feed rate. All dynamic simulations used in... 

A different multiplexing method was proposed by McLean and RusseUf utilizing rapid injection of ions into the drift tube at a frequency much faster than could be processed by a stand-alone IMS using one-dimensional time correlation creating a pseudo-continuous ion beam within the drift tube. In this instrumental arrangement, a TOFMS was utilized as a rapid and sensitive detector since both IMS and TOFMS achieve separation based on time dispersion of ions. Correlated multiplexed data acquisition allowed the use of ion injection rates much faster than that predicted to achieve 100% duty cycle in a sequential pulse-and-wait experiment, and improved usage of the bidimensional separation space. 

Until further clinical data are available, the manufacturer does not recommend continued usage of the combination beyond 3 months to 4 months. In patients taking sirolimus and eielosporin for more than 3 months, higher serum creatinine levels and lower glomerular filtration rates have been seen. Patients who were successfully withdrawn from eielosporin had improved creatinine levels, higher glomerular filtration rates and a lower risk of malignancy. ... 

---