Multiplexing Methods

Reproduced with pennission of the American Chemical Society. 

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FIGURE 6 The concentration of metabolites as measured in a multiplex method such as MS/MS of amino acids and acylcamitines can detect metabolic aberrations that are attributed to disorders with basis in genomics (inherited disease) or are due to environmental or developmental cause (nongenetic). 

Since it is likely that combined analysis of several CSF markers will be necessary to improve diagnostic performance, multiplex methods will be of importance. 

Barbastathis G, Psaltis D (2000) Volume holographic multiplexing methods. In Coufal H, Psaltis D, Sincerbox GT (eds) Holographic data storage. Springer, Berlin... 

The simplest application of these multiplexing methods involves the so-called direct-reading spectrometer , which was used with some success for a short period in atomic spectroscopy [42]. This instrument consists of a dispersion system with an array of exit silts arranged at appropriate locations. Behind each silt Is a photodetector —usually a photomultiplier. These multiplexing methods have also been used In UV-vIsIble spectroscopy, although to a lesser extent they have been Implemented on automatic discrete analysers featuring an optical system of this type with 5-10 channels or wavelengths... 

G. Barbastathis, D. Psaltis, Vdume Holographic Multiplexing Methods, in [14],... 

Today this widespread use includes a great deal of routine spectroscopic research and chemical analysis. So much so, in fact that Pierre Connes has recently expressed concern that prospective spectroscopists might indeed become "over-Fourierized". He pointed out that advantages offered by the Fourier multiplex method were not... 

Although Vkim and Vkg are generally different in different multiplexing methods, we wiU consider here the crystal angle multiplexing combined with the peristrophic rotation discussed in Section 3.4. Furthermore, for simplicity, we assume = 0° in this section. First, let us consider Vkg after the crystal angle multiplexing around the axis inclined at The matrix that rotates at around the z-axis, and subsequently rotates at around the i -axis, is expressed as... 

Barbastathis, G. Psaltis, D., (2000). Volume holographic multiplexing methods. In Holographic data storage, Coufal, H.J., Psaltis, D., Sincerbox, G.T., pp. 21-62, Springer, 978-3540666912, New York. 

Frycdk, P, Schug, K.A. (2009) High throughput multiplexed method for evaluation of enantioselective performance of chiral selectors by HPLC-ESI-MS and dynamic titration cinchona alkaloid carbamates discriminating N-blocked amino acids. Chirality, 21, 929-936. 

Frequency division multiple access (FDMA) A multiplexing method whereby each channel is assigned... 

Figure 7.16 Modulus and damping for a carbon-fibre composite measured by the frequency multiplexing method during a single thermal scan. Insert shows the Arrhenius activation-energy plot from the loss peak position.

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