Containers and Labelling

Many active substances are sensitive to light, and therefore, oral solid dosage forms have to be packaged in a light-protecting container. This is especially relevant to capsules with a transparent shell. Powders are packaged in a carton 

Single-dose powders are packaged in a suitable powder fold box, a plastic bag with locking clip or, in case of an authorised medicine, in sachets. 

Containers of solid oral dosage forms should be provided with a label. When the preparation has a primary and a secondary container, both containers should be labelled. The label should meet the requirements described in Sect 37.3. 

Carbasalate calcium is a relatively unstable solid active substance, as it degrades through hydrolysis in the presence of moisture. Upon degradation, salicylic acid and acetic acid are formed. The latter can be smelt in very low quantities. To prevent patients becoming needlessly worried, carbasalate calcium powders should be packaged in lightly ventilating material such as paper. 

---

Representative samples of each shipment must be collected for testing as required by 211.84. (b). The number of containers to be sampled depends on the (i) component variability, (ii) confidence level, (iii) degree of precision desired, (iv) past quality history of the supplier, and (v) quantity needed for analysis and reserve samples. For hazardous or highly toxic raw materials, where on-site testing may be impractical, suppliers COA should be obtained, showing that the raw materials conform to specifications. In addition, the identity of these raw materials should be confirmed by examination of containers and labels. The lack of on-site testing for hazardous raw materials should be documented. 

There should be written standard operating procedures (SOP) in place before sampling. Before sampling, the operator should have all the equipment, containers, and labels needed for sampling this information should be included in the SOP. All labels should be applied at the time of sampling. 

Field Samples. Each field sample is packed in an appropriate container and labeled. In addition to the harvest information listed above, information on the history of the sample (storage conditions and intervals) near the field location and on shipment to the laboratory is generated. 

Instruct others to keep a safe distance. Wear breathing apparatus, eye protection, laboratory coat, and PVA or Viton gloves.18 Cover spill with a 1 1 1 mixture by weight of sodium carbonate or calcium carbonate, clay cat litter (bentonite), and sand. Scoop into appropriate container and label for disposal by burning.19-21... 

Fig. 12. Diagram of the continuous neutralisation of the product of the hydrolytic condensation of ethyldichlorosilane 1,2- batch boxes 3 - neutraliser 4, 5 - collectors for complete salt separation. The liquid from the centrifuge (the finished product) is poured into collector 11, sent into containers and labeled...

Preparing solutions is important lab work. In step 1, the solute is weighed. In step 2, the solute is transferred to a volumetric flask, which holds a known volume. In step 3, enough water Is added to dissolve the solute, and then more water Is added to bring the solution volume up to the calibration mark on the flask. In step 4, the solution is shaken, stored in a stoppered container, and labeled. 

Finished Product. A product that has undergone all stages of production, induding packaging in its final container and labelling. 

While mixture is still liquid, pour into salve containers and label. Note Make sure your containers are made to withstand hot liquids before using them. 

In laboratory, small amounts of metal alkyls may be destroyed by diluting the pure compounds or its more concentrated solutions to a concentration below 5% with a hydrocarbon solvent, such as hexane or toluene. Alternatively, a water-miscible solvent, such as ethanol or ferf-butanol may be used. Small volumes of such solutions are then slowly and cautiously added to water in wide-mouthed containers in a hood and swirled gently. The metal alkyls are converted into their oxides or hydroxides. The organic solvent, if immiscible in water, is separated and evaporated in a hood. The entire content may, alternatively, be placed in waste containers and labeled for disposal. The toxic oxides or hydroxides of the metals formed are disposed for landfill burial while the nontoxic metal oxides or hydroxides conld be flushed down the drain. Alternatively, the metal alkyl solution or its waste may be diluted to a concentration below 5% with toluene or heptane. The diluted solution is then placed in a labeled container under argon for waste disposal. 

Date note the date that the material was placed in the contains and labeled. 

---