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Contact hypersensitivity antigen-presenting cells

In addition to tumor immunity, UV exposure was found to impair antigen presenting cell function, the generation of contact hypersensitivity (CHS) to chemical haptens and... [Pg.260]

Contact (or chemical) hypersensitivity reactions develop in two phases induction and elicitation (Figure 1). Induction is the development of the initial sensitization. In this phase, the chemical penetrates the epidermis. Chemicals are haptens because they are, by themselves, unable to elicit an immune response. As such, they must associate with proteins in the skin to stimulate a specific immune response. The hapten-protein complex is then processed by antigen presenting cells in the skin, transported and presented to T cells in the draining lymph nodes. This interaction leads to a proliferative response and the development of memory T cells that distribute systemically within the body. [Pg.1371]

CD8 Cell associated Antigen presented by MHC I clonal expansion of CD8 cells Activation of cytotoxic (CD-8) T cells Contact dermatitis (poison ivy) Chronic hypersensitivity pneumonitis... [Pg.546]

See other pages where Contact hypersensitivity antigen-presenting cells is mentioned: [Pg.1188]    [Pg.1335]    [Pg.124]    [Pg.127]    [Pg.1372]    [Pg.2441]    [Pg.89]    [Pg.59]    [Pg.76]    [Pg.76]    [Pg.77]    [Pg.183]    [Pg.392]    [Pg.239]    [Pg.547]    [Pg.337]    [Pg.95]    [Pg.57]    [Pg.151]    [Pg.25]    [Pg.36]    [Pg.55]    [Pg.282]    [Pg.545]    [Pg.855]    [Pg.334]    [Pg.74]    [Pg.80]   
See also in sourсe #XX -- [ Pg.93 ]



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Antigen presentation

Antigen-presenting cells

Cell contacts

Contact hypersensitivity

Hypersensitivity

Hypersensitization

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