Contact dermatitis oxytetracycline

Fawcett and Pepys (1976) reported the case of a patient who developed immediate bronchospasm and an urticarial reaction after ingestion of a commercial combination of three tetracyclines no reactions could be elicited by oral challenge with the different tetracyclines, tartrazine, or the blue coating of the drug, whereas a provocation test with the commercial preparation was positive. Other clinical patterns, such as fixed drug eruptions (Kandil 1969 Delaney 1970 Csonka et al. 1971 Brown 1974 Shimizu and Shimao 1977 Pasricha and Shukla 1979), vascular purpura (Schoenfeld 1964) and a picture similar to systemic lupus erythematosus (SLE) (Sulkowski and Haserick 1964) have also been described. Contact dermatitis seems to be a very rare complication it was, however, observed after contact with oxytetracycline (Dohn 1962 Bojs and Moller 1974) and minocycline. In the latter case subsequent oral therapy with the same drug was followed by a systemic reaction and the sensitivity was confirmed by epicutaneous tests (Shelley and Heaton 1973). 

Moller H (1976) Eczematous contact allergy to oxytetracycline and polymyxin B. Contact Dermatitis 2 289-290... 

Streptomycin is used to control bacterial plant diseases, such as fire blight. It may be used in combination with oxytetracycline and tetracycline. It has been reported to cause allergic contact dermatitis among agricultural workers [149]. 

A rare side effect of tetracycline is photoonycholysis. This reaction was observed in a woman treated for 40 days with doxycycline (200 mg/daUy) (59 ). Contact dermatitis is also a rare complication of tetracycline therapy. Three cases of eczematous contact allergy to oxytetracycline have been reported. Cross-sensitivity to tetracycline and metha-cycline could be demonstrated by patchtesting in these cases (60 ). 

Contact allergy to tetracyclines appears to be rare. Aureomycin ointment (Lederle) produced a dermatitis in a woman who applied the ointment to an area treated by dermabrasion. The patient was positive to chlortetracycline and di-methylchlortetracycline, but negative to oxytetracycline, tetracycline, and cymety-cline (Calnan 1967). Bojs and Moller (1974) reported three patients with contact allergy to oxytetracycline. Cross-sensitivity to tetracyclin and methacycline was demonstrated in two of the cases. 

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See also in sourсe #XX -- [ ]

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