Constructive combination

Biologicals. Figure 3 Fusion protein construction combination of the molecular component of interest with the constant region (Fc) of an antibody molecule, usually immunoglobulin (lg)G1 Fc, imparts the Fc function on to the molecularcomponentfortherapeutic use. The example given is ofCTLA4-lg, derivatives of which have shown clinical efficacy in the treatment of rheumatoid arthritis and transplant rejection. 

The two examples from our work we are going to describe below are the design and study of liposomal diepitope constructs combining either (i) B and T-helper (Th) peptide epitopes, which induced particularly powerful humoral responses (21) (Fig. 3) or (ii) CTL and Th epitopes, which provided a powerful antitumor vaccine (74) (Fig. 4). For the production of these constructs we have conjugated peptides that contain a cysteine residue either at the N- or C-terminus, to the surface of preformed liposomes by reaction with thiol reactive functionalized phospholipids and/or PamaCys lipopeptide anchors (Fig. 2). To that end, we have developed strategies that give, in aqueous media, high... 

Boeckler C, et al. Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes. Eur J Immunol 1999 29 2297. 

Any engineering design, particularly for a chemical process plant, is only useful when it can be translated into reality by using available materials and fabrication methods. Thus, selection of materials of construction combined with the appropriate techniques of fabrication can play a vital role in the success or failure of a new chemical plant or in the improvement of an existing facility. 

Besides, if those m.o.s were occupied, the increased electron density between the nuclei due to constructive combination of 2p orbitals (bonding m.o.) and the corresponding decreased electron density for the destructive combination (anti-bonding m.o.) would occur mainly for regions on opposite sides of the internuclear axis. Hence, the bonding and anti-bonding effects are smaller than for a m.o.s. 

Symmetry arguments have been proposed by Levitt and coworkers [77,86-88] that enable a constructive combination of both MAS and RF based on certain symmetry properties of the internal spin Hamiltonians. Two classes of symmetry sequences have been proposed, CN [86] and [87,88]. Selective recoupling or decoupling of spin interactions is possible with a suitable combination of the symmetry numbers, N, k and x- An example of RI82 for homonuclear dipolar decoupling will be discussed later. 

The Bragg equation shows that diffraction occurs when the scattering vector equals a reciprocal lattice vector. The scattering vector depends on the geometry of the experiment whereas the reciprocal lattice is determined by the orientation and the lattice parameters of the crystalline sample. Ewald s construction combines these two concepts in an intuitive way. A sphere of radius 1//1 is constructed and positioned in such a way that the Bragg equation is satisfied, and diffraction occurs, whenever a reciprocal lattice point coincides with the surface of the sphere (Figure 1.8). 

The simplest TVD schemes are constructed combining the first-order (and diffusive) upwind scheme and the second order dispersive central difference scheme. These TVD schemes are globally second order accurate, but reduce to first order accuracy at local extrema of the solution. 

The result of a flow cytometry experiment is a histogram of cell distribution by the total amount of surface-bound chemokine, with or without an unlabeled competitor Hgand. This assay provides an easy way to quickly screen numerous candidate disulfide-trapped construct combinations uHth-out the complexities of sample purification however, the utUity of this method is limited to chemokines that are detectable on the cell surface by a... 

The constructive enhancement concept in a composite is analogous to a ballet dance in which the male dancer uses his strength to help the female dancer rotate faster on her toes than she could ever do by herself. In some occasions, he also lifts her to the air to help her fly to a new height that she can never accomplish by her own ability. The beauty here is to form a complementary team so that the merits of individuals can be constructively combined and enhanced. 

We start with the first group. As already mentioned, the connectivity index x can be formally constructed combining the row sums of the adjacency matrix using the algorithm represented by S(ij) 1/ V(RiRj). where R and Rj are the row sums of a pair of adjacent vertices summed over all bonds. 

A - resilient, self-supporting bumper constructions (combination of very good flow, high stiffness, and toughness)... 

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