Construction of Artificial Self-Sufficient Fusion Proteins

3 Construction of Artificial Self-Sufficient Fusion Proteins 

For example, the N-terminal human CYP2D6 sequence was linked to the C-terminal human cytochrome reductase module, resulting in a self-sufficient enzyme exhibiting activity toward a wide range of pharmaceutical compounds such as bufuralol, metoprolol, or dextromethorphan [152]. Other examples are fusion proteins ofhumanCYPlAl with rat CPR [153], human CYP2C9 with BMR [154], and 

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