Connective tissue proteoglycan

These conformations were subjected to a combined MD/EM refinement using the NOESY derived constraints as pseudoenergy functions. Families of conformations for the whole molecule were then constructed from the structures derived for each linkage. This procedure was demonstrated on a fragment from the carbohydrate-protein linkage region of connective tissue proteoglycans. 

The ICD of the dyes bound to saccharides through an ionic coupling or hydrophobic interaction may remain a conflicting problem. The side-chain chromophores covalently bound to saccharides permit CD bands in the far or near ultraviolet region. These side-chain chromophores can exhibit CD and thus provide more definitive information on the conformation of saccharide moieties. Thus, acetamide CD has been observed to reflect polymer secondary structure of glycosaminoglycans, which are the connective-tissue proteoglycans. 

KSII is found in loose connective tissue proteoglycan aggregates with chondroitin sulfate. KS I is found in cornea. 

MOLECULAR STRUCTURE OF THE CARBOHYDRATE-PROTEIN LINKAGE REGION FRAGMENTS FROM CONNECTIVE-TISSUE PROTEOGLYCANS... 

L. Rod6n, and N. B. Schwartz, Biosynthesis of Connective Tissue Proteoglycans, in MTP International Review of Science, Biochemistry, Ser. 1, Biochemistry of Carbohydrates, (W. Whelan, Ed.), N.T. Butterworths, London (1975). 

Protein that stabilizes connective tissue proteoglycans... 

N-acetylglucosamine (see Chapter 9) is a component of glycoproteins, connective tissue proteoglycans, and complex lipids. It may be synthesized in the human organism from fructose-6-phosphate, as indicated in Figure 18.17. N-acetylglucosamine is also a precursor of N-acetylmannosamine, which along with pyruvic acid participates in the biosynthesis of sialic acid. 

R421 N. R. Krishna and P. K. Agrawal, Molecular Structure of the Carbohydrate-Protein Linkage Region Fragments from Connective-Tissue Proteoglycans , Adv. Carbohydr. Chem. Biochem., 2001, 56, 201... 

Rama Krishna N, Agrawal PK. Molecular structure of the carbohydrate-protein linkage region fragments from connective tissue proteoglycans. Adv Carbohydr Chem Biochem 2000 56 201-234. 

Figure 1. Currently accepted model for connective tissue proteoglycan aggregate...

Roden, L. (1980). Structure and Metabolism of Connective Tissue Proteoglycans in The Biochemistry of Glycoproteins and Proteoglycans (Lennarz, W., ed.). Plenum Press, New York and London, pp. 267-371. 

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