Connective tissue cellular differentiation

The various components of the nervous system can be further differentiated into three basic cellular elements (1) neurons, (2) interstitial cells, and (3) connective tissue, blood vessels, and microglia. The neuron is the only cell type in the nervous system involved in information processing. Each neuron is, in its own right, a receiver, an integrator, and a transmitter of information. Neurons are always in contact with other neurons so that they create simple or complex channels through which many different responses can be transmitted. All behavior, no matter how complex, results from the interactive function of the billions of neurons. 

The skeleton is the body s principal reservoir of calcium and phosphorus. Contrary to its appearance, bone is a dynamic tissue, and calcium and phosphate are continuously deposited and released. Bone is a modified connective tissue consisting of a cellular component, an organic matrix and an inorganic (mineral) phase. Its cells are osteoblasts, osteoclasts, osteocytes, and osteoprogenitor cells. The last are a type of mesenchymal cell that can differentiate into any of the other three types and to which the other types can revert. 

Determining which specific cellular effects of ascorbate can be demonstrated in vitro. In this context particular attention will be paid to studies undertaken to relate the role of ascorbate in connective tissue differentiation to the pathogenic events in severe ascorbate deficiency, i.e., scurvy, which with confidence may be rated as a connective tissue disease. 

As a natural constituent of connective tissue and major structural protein, collagen is implicated in all phases of the wound healing process (hemostasis, inflammation, migration, proliferation and maturation) and controls the cellular functions such as cell shape and differentiation, migration, and synthesis of a number of proteins [100]. The use of collagen dressings may seem attractive in view of their functions to ... 

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