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Conjugation acetylation

Metabolism - Metabolism occurs in the liver by conjugation, acetylation, and other metabolic pathways to inactive metabolites. [Pg.1702]

A-acetyl transferases Amino acid conjugation Cytosohc Mitochondria, microsomal Acetylation Conjugation Acetyl-coenzyme A Acyl-CoA, serine, proline 2 [120]... [Pg.280]

Mercapturlc acids are most easily obtained by acetylation of the corresponding cysteine conjugates. Acetylating agents such as acetic anhydride (1 ) and ketene (183) may be used. [Pg.144]

Methyl group (Section 2 7) The group —CH3 Mevalonic acid (Section 26 10) An intermediate in the biosyn thesis of steroids from acetyl coenzyme A Micelle (Section 19 5) A sphencal aggregate of species such as carboxylate salts of fatty acids that contain a lipophilic end and a hydrophilic end Micelles containing 50-100 car boxylate salts of fatty acids are soaps Michael addition (Sections 18 13 and 21 9) The conjugate ad dition of a carbanion (usually an enolate) to an a 3 unsatu rated carbonyl compound... [Pg.1288]

Conjugated dienes, upon complexation with metal carbonyl complexes, are activated for Friedel-Crafts acylation reaction at the akyhc position. Such reactions are increasingly being used in the stereoselective synthesis of acylated dienes. Friedel-Crafts acetylation of... [Pg.562]

An alternate method for preparing a A -acetoxypregnane from A -20-keto starting materials involves the conjugate 1,4-addition of a Grignard reagent to C-16, followed by acetylation of the resulting enolate before work-... [Pg.186]

FIGURE 25.7 The pathway of palmhate synthesis from acetyl-CoA and malonyl-CoA. Acetyl and malonyl building blocks are introduced as acyl carrier protein conjugates. Decarboxylation drives the /3-ketoacyl-ACP synthase and results in the addition of two-carbon units to the growing chain. Concentrations of free fatty acids are extremely low in most cells, and newly synthesized fatty acids exist primarily as acyl-CoA esters. [Pg.809]

V,7V-dimethylaminopyridme provides l-(2-methoxycarbonyl)ethoxy- (40,69%) and l-(2-methoxycarbonyl-l-methyl)ethoxytryptamine (41, 72%), respectively (Scheme 4). The conjugate addition to mesityl oxide proceeds successfully as well, giving iVb-acetyl-1-(1, l-dimethyl-3-oxo)butoxytryptamine (42,49%), while the reaction with methyl 3-methylcrotonate affords 43 in a miserable yield (1.6%). Addition to acrolein results in failure, and 44 is not yet obtained. [Pg.110]

Step 2 of Figure 29.12 Isomerization Citrate, a prochiral tertiary alcohol, is next converted into its isomer, (2, 35)-isocitrate, a chiral secondary alcohol. The isomerization occurs in two steps, both of which are catalyzed by the same aconitase enzyme. The initial step is an ElcB dehydration of a /3-hydroxy acid to give cfs-aconitate, the same sort of reaction that occurs in step 9 of glycolysis (Figure 29.7). The second step is a conjugate nucleophilic addition of water to the C=C bond (Section 19.13). The dehydration of citrate takes place specifically on the pro-R arm—the one derived from oxaloacetate—rather than on the pro-S arm derived from acetyl CoA. [Pg.1156]

JV-Acetyltransferases (NATs) catalyze the conjugation of an acetyl group from acetyl-CoA on to an amine, hydrazine or hydroxylamine moiety of an aromatic compound. NATs are involved in a variety of phase II-diug metabolizing processes. There are two isozymes NAT I and NAT II, which possess different substrate specificity profiles. The genes encoding NAT I and NAT II are both multi-allelic. Especially for NAT II, genetic polymoiphisms have been shown to result in different phenotypes (e.g., fast and slow acetylators). [Pg.12]


See other pages where Conjugation acetylation is mentioned: [Pg.18]    [Pg.218]    [Pg.339]    [Pg.170]    [Pg.181]    [Pg.46]    [Pg.147]    [Pg.184]    [Pg.112]    [Pg.26]    [Pg.16]    [Pg.1609]    [Pg.662]    [Pg.87]    [Pg.137]    [Pg.69]    [Pg.256]    [Pg.14]    [Pg.316]    [Pg.747]    [Pg.1081]    [Pg.188]    [Pg.18]    [Pg.218]    [Pg.339]    [Pg.170]    [Pg.181]    [Pg.46]    [Pg.147]    [Pg.184]    [Pg.112]    [Pg.26]    [Pg.16]    [Pg.1609]    [Pg.662]    [Pg.87]    [Pg.137]    [Pg.69]    [Pg.256]    [Pg.14]    [Pg.316]    [Pg.747]    [Pg.1081]    [Pg.188]    [Pg.102]    [Pg.16]    [Pg.193]    [Pg.452]    [Pg.642]    [Pg.287]    [Pg.93]    [Pg.157]    [Pg.174]    [Pg.183]    [Pg.190]    [Pg.334]    [Pg.340]    [Pg.66]    [Pg.205]    [Pg.208]    [Pg.215]   
See also in sourсe #XX -- [ Pg.48 ]

See also in sourсe #XX -- [ Pg.290 , Pg.291 ]




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Acetyl conjugation

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