Conjugates, of steroid hormones,

MRP1 (ABCC1) Glucuronides and sulfate conjugates of steroid hormones and bile salts, colchicine, doxorubicin, daunorubicin, epirubicin, folate, irinotecan, methotrexate, pacitaxel, vinblastine, vincristine, and others... [Pg.7]

Kidd. K. E.. and BlickenSteroid Hormones. Nev( York. Academic Press. 1969. [Pg.139]

OATP transporters, SLCOICI, SLC02B1, SLC03A1, SLC04A1, and SLC04C1 have been found in the jejunum, and also in the colon, with the exception of SLC03A1 [3[. OATP-B (SLC02B1) accepts bile salts, as well as pravastatin (XIII) and sulfate conjugates of steroid hormones, and is localized in the apical membrane of enterocytes [32]. [Pg.235]

Several glucuronide conjugates of steroid hormones have a cholestatic activity. This concerns glucuronide conjugates at the D-rlng... [Pg.292]

It is probable that other conjugates of steroid hormones and their metabolites will eventually be found to exist in human urine, either as normal or unusual constituents. A conjugate of 17a-estradiol with jS-glucuronic acid and IV-acetylglucosamine has been isolated recently (J3) and an unusual compound, not a conjugate in the usual sense, of urea and... [Pg.62]

The synthesis of alkylating agent conjugates of steroidal hormones led to compounds with enhanced selectivity due to improved transport properties of the hormone to particular... [Pg.109]

A full account of the further metabolism and conjugation of steroid hormones is beyond the scope of this chapter, but a few remarks might be germane. Oestrogens can be transformed into the corresponding glycosides, sul-... [Pg.41]

The labelling of steroid hormone-receptor ligands is important, since it would probably allow early detection and treatment of breast and prostate cancer. Attempts to apply the second-generation approach in which a chelator is conjugated to the steroid have been made, but with little success so far. Both the [3 + 1] approach and derivatization of the [Tc(CO)3]" core have been... [Pg.253]

Schlusener MP, Bester K (2005) Determination of steroid hormones, hormone conjugates and macrolide antibiotics in influents and effluents of sewage treatment plants utilizing high-performance liquid chromatography/tandem mass spectrometry with electrospray and atmospheric pressure chemical ionization. Rapid Commun Mass Spectrom 19 3269-3278... [Pg.281]

SULT 2A and 2B sulfotransferase subfamily members sulfate the 3P-hydroxyl group of a variety of steroid hormones. Dehydroepiandrosterone (DHEA) is the prototypical substrate for the SULT 2 enzymes. However, other hydroxysteroids such as testosterone and its phase I hydroxylated derivatives are substrates for these enzymes. The SULT 2 sulfotransferases also are responsible for the sulfate conjugation of a variety of alcohols and xenobiotics that have undergone phase I hydro-xylation, including the polycyclic aromatic hydrocarbons (PAHs). The SULT 2 enzymes exhibit different patterns of tissue expression. SULT 2A1 is expressed primarily in the adrenal cortex, brain, liver, and intestine, while SULT 2B1 is expressed in the prostate, placenta, and trachea. [Pg.225]

A bibliography of steroid conjugates as well as a treatise on the metabolism of steroid hormones have been published. The abstracts of papers presented at the Second International Congress of Hormonal Steroids are available. ... [Pg.208]

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