Configuration of Enzyme Reactors

Immobilized enzyme and enzyme membrane reactors each have advantages and disadvantages (Table 5.1). 

Membrane reactors - no mass transfer limitations - pyrogen-free products - scale-up simple - pre-filtration required - no polymeric products possible - no product precipitation possible 

Immobilized enzyme reactors - potentially more stable enzymes - co-immobilization possible - difficult to sterilize - mass transfer limitations - immobilization increases costs 

Immobilization influences the activity and stability of biocatalysts much more than encapsulation by membranes however, enhanced activity (rarely) or stability (often) can be an important reason to pick immobilization for the retention of enzymes. 

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