Concluding Remarks and Future Prospects

Fendler, Adv. Phys. Org. Chem. 1970, 8, 271 (c) Y. Moroi, Micelles Theoretical and Applied Aspects, Plenum, New York, 1992, p. 41 (d) C. Tanford, The Hydrophobic Effect Formation of Micelles and Biological Membranes, Wiley, New York, 1980, p. 42. 

Wolfgang A. Herrmann, Robert W. Ecill, Fritz E. Kuhn 

The majority of chiral ligands for asymmetric catalysis in a homogeneous phase consists of tertiary phosphines, and this is also true for aqueous-phase catalysis. This section concentrates on the different approaches to achieve solubilization of these ligands in water. 

Recently, there have been some collective efforts to increase the spatial resolution of the HX-MS technique by further fragmenting the peptides by electron transfer/capture dissociation (ETD or ECD) (see Chapters 8 and 9). The methodologies described in this chapter should also apply to ETD/ ECD data because the fragments generated from ETD/ECD can be treated similarly to overlapping peptides generated by the protease. 

Gas-Phase Fragmentation of Peptides to Increase the Spatial Resolution of the Hydrogen Exchange Mass Spectrometry Experiment 

Pemille Foged Jensen and Kasper D. Rand Department of Pharmacy, University of Copenhagen, Copenhagen, Denmark 

Hydrogen Exchange Mass Spectrometry of Proteins Fundamentals, Methods, and Applications, First Edition. Edited by David D. Weis. 

Multiple studies have shown that the use of fragmentation techniques based on slow vibrational excitation of gaseous peptide ions (such as CID) induce complete intramolecular migration of deuteriums during activation [12,26-33]. While a number of early studies reported little or no scrambling in fragment ions produced by CID [13,14,16,17], other reports using well-characterized model peptides and 

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Mono(ADP-ribosyl)ation Reactions Bacterial ADP-ribosylating Toxins Concluding Remarks and Future Prospects... 

F. A Brief Comment on Semiclassical Theories Hierarchical Regularity in Transition States Concluding Remarks and Future Prospects Acknowledgments... 

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