Computer programs NONMEM

The graphs and examples are geared toward NONMEM simply because NONMEM is the most widely used computer program for population PK/PD analysis. The principles, on the other hand, are quite general and should be easily adoptable for use with other software employing the same methodological strategy as NONMEM does. 

NONMEM is provided as FORTRAN source code for UNIX, IBM, and other computers. The program performs non-linear regression of individual or population data. 

L. Lindbom, J. Ribbing, and E. N. Jonsson, Perl-speaks-NONMEM (PsN)—a Perl module for NONMEM related programming. Comput Methods Programs Biomed 75 85-94 (2004). 

E. N. Jonsson and M. O. Karlsson, Xpose—an S-PLUS based popnlation pharmacoki-netic/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed 58 51-64 (1999). 

---