Computer-aided process simulation

Both the need to reduce experimental costs and increasing reHabiHty of mathematical modeling have led to growing acceptance of computer-aided process analysis and simulation, although modeling should not be considered a substitute for either practical experience or reHable experimental data. 

The use of the computer in the design of chemical processes requires a framework for depiction and computation completely different from that of traditional CAD/CAM appHcations. Eor this reason, most practitioners use computer-aided process design to designate those approaches that are used to model the performance of individual unit operations, to compute heat and material balances, and to perform thermodynamic and transport analyses. Typical process simulators have, at their core, techniques for the management of massive arrays of data, computational engines to solve sparse matrices, and unit-operation-specific computational subroutines. 

Flash-drum specifications in addition to (T9, T9) and (T9, adiabatic) are also possible but must be applied with care, as discussed by Michelsen [Comp. Chem. Engng., 17,431 (1993)]. Most computer-aided process design and simulation programs permit a wide variety of flash specifications. 

Computer-aided flow-simulation programs are also available for dies. All the programs can successfully predict a certain amount of shrinkage under specific conditions that can be applied to experience. The actual shrinkage is finally determined after molding or extruding the products. When not in spec process control changes can meet the requirements unless some drastic error had been included in the analysis. 

Dinh, B., Mauborgne, B., Baron, P. 1992. Dynamic simulation of extraction operations Application in nuclear fuel reprocessing. In European Symposium on Computer Aided Process Engineering-2, ESCAPE 2, October 5-7, Toulouse, France. 

Schneider R, Kenig EY, Gorak A. Complex reactive absorption processes model optimization and dynamic column simulation. Proceedings of ESCAPE 11 European Symposium on Computer-Aided Process Engineering, Kolding, Denmark, 2001. 

AIChE Today Series, "Computer Aided Process Design and Simulation", 345 E. 47th St., New York. 

The next two examples pursue this line of thought further wherein we analyze a computer-aided process of human insulin production.15 This is then followed by an analysis of process simulation of heparinase I production from E. coli.5... 

Some important chemical engineering modelling and simulation fields as well as related activities are briefly presented here. First, we can see that the traditional modelling procedures or computer-aided process engineering cover a much narrower range of modelling tools than those mentioned here. A broader spectrum of... 

Perkins, J. D., and Sargent, R. W., SPEEDUP A computer program for steady-state and dynamic simulation and design of chemical processes. Selected topics on computer-aided process design and analysis. AIChE Symp. Ser. 214, 78 (1982). 

Perkins, J. D., and Barton, G. W., Modelling and simulation in process operation. In Foundations of Computer-Aided Process Operations (G. V. Reklaitis and H. D. Spriggs, eds.). CACHE Corp., Austin, TX, and Elsevier, New York, 1987. 

R. W. H. Sargent, J. D. Perkins, and S, Thomas, "Speedup Simulation Program for Economic Evaluation and Design of Unified Processes, in Computer-Aided Process Plant Design, M. E. Leesley, ed., Gulf Publishing Company, Houston, 1982. 

Bruce S. Hoiden, M.S. Process Research Leader, The Dow Chemical Company Member, American Institute of Chemical Engineers [Process Fundamentals and Basic Calculation Methods, Calculation Procedures, Computer-Aided Calculations (Simulations), Single-Solvent Fractional Extraction with Extract Reflux, Liquid-Liquid Phase Separation Equipment]... 

More recant efforts to develop computer-aided process synthesis methodologies can be cbeincterized as either sequential modular, simultaneous modular, or equation oriented, Sequeatial-modular approaches are ben for steady-state simulation where process inputs are defined and process para met ara ate available. The best feature of sequential-modular approaches is that they are flowsheet oriented, bot they are not as flexible as the other methodologies in parfonuing design and optimization tasks.39... 

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