Lozenges compressed tablet

Lozenges These are compressed tablets formulated, without a disintegrant and must be allowed to dissolve in the mouth. They are used for local activity (throat lozenges) or for systemic effect (vitamins). Effervescent tablets These tablets undergo quick dissolution of actives in water due to internal liberation of carbon dioxide. By combining alkali metal carbonates or bicarbonates with tartaric or citric acid, carbon dioxide is liberated when placed in water. 

Lozenges can be made by molding or by compression at high pressures, often following wet granulation, resulting in a mechanically strong tablet that can dissolve... 

The sugar bases frequently associated with lozenge tablets are sucrose or compressible sugar, dextrose, mannitol, and sorbitol, which are available in special... 

Mannitol is an isomer of sorbitol. Like the latter, it has a negative heat of solution which makes it a useful excipient for chewable tablets and lozenges. It is less hygroscopic than sorbitol and has about one-tenth of the solubility in water. Similarly to sorbitol, several polymorphic forms are available which differ in their ability to form tablets. " However, unmodified mannitol cannot be used for direct compression because of poor flow and binding properties. Directly compressible forms are available in a range of particle sizes which are reported to produce excellent tablets. 

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