Compounds, special classes steroids

Isolation of Processes To minimize cross-contamination and microbiological contamination, the manufacturer may develop special procedures for the isolation of processes. The level of facilities isolation depends on the types of products to be manufactured. For instance, steroids and sulfas require more isolation than over-the-counter (OTC) oral products [6], To minimize exposure of personnel to drug aerosols and loss of product, a sealed pressure vessel must be used to compound aerosol suspensions and emulsions [21], An example of cross-contamination with steroids was the controversial case of a topical drug manufactured for the treatment of skin diseases. Fligh-performance liquid chromatography/ultraviolet and mass spectrometry (FIPLC/UV, FIPLC/MS) techniques were used by the FDA for the detection of clobetasol propionate, a class 1 superpotent steroid, as an undeclared steroid in zinc pyrithione formulations. The product was forbidden and a warning was widely published [22],... 

When the paper is impregnated with an organic liquid, the drying period is shortened to remove only the volatile mobile phase. The theory of unidimensional multiple development has been described [48], and the method has been used to analyze steroids [49] and amino acids [50] among other classes of compounds. Fractional chromatography is a special variation of multiple development in which a solvent of increasing polarity is employed for each subsequent development [51]. 

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