Compounds Derived from Phenylacetic Acid

Martin, Aromatic Hydroxyketones Preparation and Physical Properties, 

Jv COCH2 —- Obtained by reaction of bromine with 4-phe-I ij nylacetyl-pyrogallol in acetic acid [5182], at 

NO2 C0CH2- Preparation by Fries rearrangement of L ij 2,6-di(phenyl-acetoxy)niliobenzene(m.p. 124 ) 

COCH2—- Obtained by reaction of fuming nitric acid (d = 1.5) with 4-phenylacetylresorcinol in HO acetic acid in an ice bath for 48 h [5175]. 

It is not mentioned in the Chemical Abstracts between 1907 (volume 1) and 2000 (volume 133) under the various denominations, namely m-Hydroxy-a-phenylace-tophenone, 3 -Hydroxy-2-phenyl-acetophenone and actually l-(3-Hydroxyphenyl)-2-phenylethanone, neither in the Beilsteins Handbuch der Organischen Chemie under the denomination [3-Oxy-phenyl]-benzyl-keton. This ketone might very likely be prepared more simply by diazotization of the l-(3-aminophenyl)-2-phenylethanone [55251-36-0], an amino ketone known for a long time [5227]. 

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For the preparation of long chain alkanes from fatty acids it is useful to extract the electrolyte contin-ously with a high-boiling nonpolar solvent, e.g. 2-methylheptane. Cyclopropanecarboxylic acids in some cases have been dimerized, e.g. or (15) in other cases the radical is further oxidized to a carbocation which then undergoes ring opening and solvoiysis to allylic compounds. Specifically substituted 1,2-diphenyiethanes have been prepared from phenylacetic acids (Table 2, entries 22 and 23). A variety of 2,3-disubstituted succinic acids and their derivatives have become accessible from malonic... 

In practically all theories of the biosynthesis of quinazolines, anthranilic acid or an equivalent is regarded as one of the building blocks. Robinson 158) postulated that anthranilic acid (N-methylated where necessary), ammonia or amine, and formic acid or phenylacetic acid derived from phenylalanine units or their equivalents build up the simple substituted quinazoline derivatives. Thus vasicine (28) may be derived from anthranilic acid and proline, or closely related metabolites. Febrifugine (9) possibly could be formed from anthranilic acid, formic acid, ammonia, a Cj-unit, and lysine or equivalent compounds. For... 

Compounds Derived from Substituted Phenylacetic Acids... 

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