Polyamine gold complexes

Carotti, S., Guerri, A., Mazzei, T., Messori, L., Mini, E. and Orioli, P. (1998) Gold(III) compounds as potential antitumor agents Cytotoxidty and DNA binding properties of some selected polyamine-gold(III) complexes. Inorganica Chimica Acta, 281, 90. 

Kimura, E., Kurogi, Y. and Takahashi, T. (1991) The first gold(III) macrocydic polyamine complexes and application to selective gold(III) uptake. Inorganic Chemistry, 30, 4117. 

Complexes of other metals are used to sensitize emulsions, and some are used to sensitize even further (supersensitize) gold-sensitized emulsions. " Among these are (NH4)2[PtCl4], (NH4)2[PdCl4], (NH4)2[PdCy, K2[IrCl6] and similar compounds with ruthenium and the other halides. Sensitization by iridium salts and complex ions has been reviewed recently. Mechanisms of action of palladium(II) salts and complex ions on gold-sensitized emulsions have been studied. Several phosphine complexes of palladium and platinum, for example (2), are reported to be effective sensitizers, as are many macrocyclic polyamine compounds and their metal complexes,for example the Cu", Ni", Fe " and Rh " chelates of the cyclen ligand, 1,4,7,10-tetraazacyclododecane (3). 

Adenosine nucleotides were also electrochemically detected with ICSs. " For these purposes, gold electrodes were functionalized by covalent anchoring of macrocyclic polyamines. [Ru(NFl3)6] was used as redox probe for the voltammetric detection of ATP, ADP, and AMP. The response mechanism originates from the inhibition of the redox reaction of the marker upon formation of supramolecular complexes between macrocyclic polyamine hosts and adenine nucleotide guests at the surface of the electrode. 

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