Complete induction

The effect of 6-substitution appeared to be almost completely inductive. Dissociation constants of 4-substituted pyrimidines correlated best with [Pg.130]

Switch to oral valganciclovir (900 mg p.o. b.i.d.) to complete induction therapy once the presenting clinical manifestations have resolved... 

Azithromycin is efficacious in animal models of toxoplasmic encephalitis. In a Phase I/II dose-escalation stndy of pyrimethamine (50 mg/day) plus azithromycin (900,1200, or 1500 mg/day) for induction and maintenance treatment in 30 patients with AIDS and definite or snspected Toxoplasma encephalitis, the overall response rate was 67% after 6 weeks of induction therapy (1). However, maintenance therapy for 24 weeks with this combination was associated with a high relapse rate (47%) only six patients snccessfully completed induction and maintenance therapy. Adverse events were common (particn-larly in those taking azithromycin 1500 mg) and inclnded hepatotoxicity, bone marrow suppression, ototoxicity, and gastrointestinal disturbances, which led 20% of patients to withdraw. All adverse events resolved on withdrawal. 

Wc now employ tills result to prove bj complete induction that in general (i.e., for arbitrary n N)... 

This equation can be veriHed by complete induction, since obviously the integral is given by... 

An isotope effect of k lkj) = 0.948 has been determined for the acid-catalysed hydrolysis of l-azabicyclo[l,l,0]butane (524) and is thought to be consistent with a completely inductive or field transmission of the /3-deuterium... 

In addition to the initial reaction between nitric acid and acetic anhydride, subsequent changes lead to the quantitative formation of tetranitromethane in an equimolar mixture of nitric acid and acetic anhydride this reaction was half completed in 1-2 days. An investigation of the kinetics of this reaction showed it to have an induction period of 2-3 h for the solutions examined ([acetyl nitrate] = 0-7 mol 1 ), after which the rate adopted a form approximately of the first order with a half-life of about a day, close to that observed in the preparative experiment mentioned. In confirmation of this, recent workers have found the half-life of a solution at 25 °C of 0-05 mol 1 of nitric acid to be about 2 days. ... 

Electron Delocalization in the Conjugate Base With a of —1 4 nitnc acid is almost completely ionized m water If we look at the Lewis structure of nitric acid m light of what we have said about inductive effects we can see why The N atom m nitric acid IS not only electronegative m its own right but bears a formal charge of +1 which enhances its ability to attract electrons away from the —OH group... 

Inhibitors and retarders differ in the extent to which they interfere with polymerization, and not in their essential activity. An inhibitor is defined as a substance which blocks polymerization completely until it is either removed or consumed. Thus failure to totally eliminate an inhibitor from purified monomer will result in an induction period in which the inhibitor is first converted to an inert form before polymerization can begin. A retarder is less efficient and merely slows down the polymerization process by competing for radicals. 

Rubidium metal is commeicially available in essentially two grades, 99 + % and 99.9 + %. The main impurities ate other alkali metals. Rubidium compounds are available in a variety of grades from 99% to 99.99 + %. Manufacturers and suppliers of mbidium metal and mbidium compounds usually supply a complete certificate of analysis upon request. Analyses of metal impurities in mbidium compounds are determined by atomic absorption or inductive coupled plasma spectroscopy (icp). Other metallic impurities, such as sodium and potassium, are determined by atomic absorption or emission spectrograph. For analysis, mbidium metal is converted to a compound such as mbidium chloride. 

The inductive reactance, Xl, will tend to offset the ground capacitive reactance X,j and diminish the denominator to a certain value of Xl, say, until it completely offsets the content of X. (Xl= X, ). At higher ratios, when Xl > 3 X. g, the denominator will rise more rapidly than the numerator and will tend to attenuate the Fg a as withand X, but at a slightly higher value of max (Figure 20.7, curve 3). 

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