Complementary Strategies

In addition, a recent report details a very efficient nonenzymatic method for the asymmetric oxidation of sulfides this employs an organo-vanadium species featuring the imine (38) (Scheme 25)[111]. A second, complementary strategy for the preparation of optically active sulfoxides involves the enantioselective oxidation of racemic sulfoxides. ... 

We used our computationally based model to design and assess a series of chiral rho-dium(II) carboxylates. It was quickly apparent that although others achieved some success with chiral monocarboxylates [24, 25], designs based on simple monocarboxylates were too flexible to allow rational design. We are therefore pursuing two complementary strategies (1) the use of ortho-metallated head-to-tail triarylphosphine complexes, and (2) the use of bridging diacids. 

All approaches to the design of enantiomerically pure rhodium(II) catalysts had depended on the attachment of enantiomerically pure ligands to the rhodium core. In collaboration with Professor Pascual Lahuerta of the University of Valencia, Spain, we undertook a complementary strategy, the preparation of rhodium(I I)-dimers (P)-56 and its enantiomer (M)-56, having backbone chirality [23]. Using the approach outlined above, we calculated that the transition state 52 should be favored over the transition state 53 by 4.2 kcal moU. ... 

Head and neck cancers afflict about one half million patients each year. First-line treatment with chemotherapy induces a response in only 30% to 40% of patients, and tumors frequently recur. Alternative or complementary strategies have been based on oncolytic viruses that selectively attack tumor cells but not normal ones. One of these viruses, Onyx-015, is a modihed adenovirus, a DNA virus that takes over the cell s protein synthesis machinery,rephcates, then lyses the host cell to release its progeny. 

Dihydropyrans of general structure 110 can be prepared by two complementary strategies starting from aldehyde 113 (or its synthetic equivalent). Condensation with vinylsilane 114 or allylsilane 115 affords in each case the adduct 110 (Scheme 13.41). 

As a complementary strategy, we will redone the inserts of our new X-ZAP 11 library into the modified pJuFo vector pGA [46 and Achatz et al., unpubl. obs.] and select for IgE-binding phagemids as well as for phagemids binding our polyclonal rabbit serum. 

In order to improve the stamping resolution of the elasomeric stamp, there have been recent improvements in both the stamp and molecular inks e.g., alkylthiols, silanes). In particular, traditional PDMS exhibits a relatively high elasticity that limits possible relief linewidths on the other hand, small molecular weight inks exhibit diffusion during patterning. Hence, the following complementary strategies have been employed ... 

The different but complementary strategies for redesigning natural enzyme can be approached from the perspective of how rational the strategy could be. Thus, the existing biocatalyst can be fine-tuned by rational design, being information intensive and computer assisted. In other words, the more rational the desired approach, the more knowledge is necessary to exactly interplay protein sequence and function. 

We follow a different, complementary strategy based on the definition of extremely simple (toy) models for the material where only few interactions are accounted for. Toy models are easily diagonalized on large systems, and an enormous amount of calculations can be performed testing different parameters regimes at an irrelevant fraction of the computational power required by quantum chemical calculations. This opens the way to appreciate the role of different interactions... 

RTlLs exhibit a variety of desirable properties, such as negligible vapour pressure, which makes them interesting for various applications. In particular, the option of fine-tuning chemical and physical properties by an appropriate choice of cations and anions has stimulated much of the current excitement with respect to these compounds and has led to the term designer solvents . An alternative, complementary strategy to tailor properties is not only to mix two (or more) ionic liquids but also to mix ionic liquids with molecular solvents. 

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