Glucoamylase commercial enzyme process

Publications giving the details of the actual development work in establishing industrial microbial enzyme processes are non-existent. It is, therefore, of interest to describe the development of a commercial enzyme process for one of the most important industrial enzymes, glucoamylase. Although there are many patents and publications on glucoamylase, nowhere has there previously been an attempt to gather together the available published and unpublished non-confidential information into a coherent report. 

TkyTicroorganisms as sources for the practical production of enzymes have several advantages over other possible sources. A wide variety of enzymes from microbial strains, selected partially on the basis of their high yields of specific enzymes, can be obtained conveniently by fermentation in unlimited quantities and in a very reproducible manner. Nevertheless, the development of a process for production of a commercial microbial enzyme frequently is a long term endeavor and involves a number of steps. Glucoamylase, for example, was clearly established as a glucogenic enzyme in 1948, but it was not in commercial usage until 1959. 

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