Comedolytic activity

Azelaic acid (Azelex) has antibacterial, antiinflammatory, and comedolytic activity. 

Azelaic acid has a dicarboxyhc acid structure that confers antibacterial, anti-inflammatory, and comedolytic activity. Azelaic acid is nsefnl for treating mild to moderate acne in patients who do not tolerate BPO. It is useful in treating postinflammatory hyperpigmentation since it also has skin-lightening properties. ... 

Retinaldehyde is biotransformed into all-frani -retinoic acid and induces biologic effects including comedolytic activity similar to those of topical tretinoin when administered at comparatively lower concentrations. ... 

Benzoyl peroxide exercises a potent antimicrobial activity through the release of free oxygen radicals. It suppresses P. acnes in sebaceous follicles much faster than antibiotics, leading to a rapid reduction of the inflammatory lesions number. P. acnes does not develop resistance to benzoyl peroxide, which maintains its efficacy after years of use. Benzoyl peroxide seems to have a mild comedolytic effect while it is not... 

Benzoyl peroxide is easy to use and recommended as first-line therapy in the treatment of mild to moderate noninflammatory acne. Benzoyl peroxide has a comedolytic effect that increases the rate of epithelial cell turnover and helps to unclog blocked pores. It also has antibacterial activity against P. acnes, which appears to be the main reason for the effectiveness of this product.13... 

Adapalene (Differin) is a third-generation retinoid with comedolytic, kera-tolytic, and antiinflammatory activity, ft is available as 0.1% gel, cream, alcoholic solution, and pledgets. A 0.3% gel formulation is also available. 

Clindamycin inhibits P. acnes and provides comedolytic and antiinflammatory activity. 

Benzoyl peroxide is an effective topical agent in the treatment of acnevulgaris. It penetrates the stratum corneum or follicular openings unchanged and is converted metabolically to benzoic acid within the epidermis and dermis. Less than 5% of an applied dose is absorbed from the skin in an 8-hour period. It has been postulated that the mechanism of action of benzoyl peroxide in acne is related to its antimicrobial activity against P acnes and to its peeling and comedolytic effects. 

It has been postulated that the mechanism of action of benzoyl peroxide in acne is related to its antimicrobial activity against P acnes and to its peeling and comedolytic effects. 

Adapalene, a third-generation retinoid, is a retinoid-mimetic com-ponnd (a naphthoic acid derivative), available as 0.1% gel, cream, alcoholic solntion, and pledgets. It has selective affinity for retinoic acid receptor (RAR) subtypes RAR- 8 and RAR-y fonnd in the epidermis," " " and has comedolytic, keratolytic, and anti-inflammatory activity. " " " Vehicle-controlled and comparative stndies have demonstrated the utility of adapalene in treatment of acne." " " Adapalene is indicated for mild to moderate acne vnlgaris. Adapalene 0.1% gel may be used as an alternative to tretinoin 0.025% gel to achieve better tolerability in some patients." " Adapalene coadministered with a topical or oral antibiotic represents arational therapy for moderate forms of acne."... 

Topical clindamycin inhibits P. acnes and provides comedolytic as well as anti-inflammatory activity. It is available in gel, lotion, solution, and disposable pad formulations, and is usually applied twice daily. Combination with BPO increases efficacy. Though rare, diarrhea and pseudomembranous colitis may occur secondary to topical clindamycin. ... 

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