Combinatorial libraries receptors simultaneously

An extension of this FTICR mass spectrometry-based screening technique has been to screen a combinatorial library for ligands to two receptors simultaneously (59, 60). In this example, the two receptors consisting of RNA constructs representing the prokaryotic (16s) rRNA and eukaryotic (18s) rRNA A-site were incubated simultaneously with an aminogly-... 

This rationale led Severin et alP to construct an array consisting of CuCh, NiCh, and three UV-active chro-mophores, resulting in six metal-indicator combinations to comprise a dynamic combinatorial library. A dynamic combinatorial library is an array of differential sensors that are simultaneously present in one solution, under thermodynamic control, such that this one solution can provide multiple signals from the composite interactions of an analyte with all the sensors in solution. They found that this simple dynamic combinatorial library of receptors was able to successfully discriminate two angiotensin peptides (angiotensin I and angiotensin II) and mixtures of these two peptides. 

---