Combinatorial electrochemistry

Reddington E, Sapienza A, Gurau B, et al. 1998. Combinatorial electrochemistry A highly parallel, optical screening method for discovery of better electrocatalysts. Science 280 1735-1737. 

A general purpose set-up for combinatorial electrochemistry was developed by a combination of a mechanical robot and electrochemical system.4041 The set-up can operate with one electrode set (consisting of classical three-electrode configuration) moving it between different cells or with 8-electrode set providing... 

Abstract The scope of this chapter is to present the current state of the art in the field of combinatorial electrochemistry with the main focus on plate-based technologies. In particular, it is focused on the development and use of electrochemical robotic systems. 

To date, combinatorial libraries are screened mainly by optical detection using for example UV/Vis absorbance or fluorescence as readout. Nevertheless, the obvious advantages of electrochemical over classical redox reactions only slowly found use in combinatorial chemistry, which is illustrated by the fact that the term combinatorial electrochemistry was introduced only in 1998 by Reddington et al.16. They first used... 

Oxidation of parent organics has also been extensively investigated using voltammetry leading to both anodic substitution and coupling. For example, the voltammetry of a large number of heterocyclic derivatives has been probed and compounds prepared through the anodic methoxylation of acylated heterocycles, in peptidomimetics, and in the first example of combinatorial electrochemistry. 

Yudin AK, Siu T (2001) Combinatorial electrochemistry. Curr Opin Chem Biol 5 269-272... 

Choi WC, Kim DJ, Woo SI. Quaternary Pt-based electrocatalyst for methanol oxidation by combinatorial electrochemistry. Catalysis Today 2002 74 235-40. 

Figure 12.6. A Pt-Rh-Os ternary array in 6 M aqueous methanol solution containing a quinine indicator [9]. (From Reddington E, Sapienza A, Gurau B, Viswanathan R, Satangapani S, Smotkin ES, et al. Combinatorial electrochemistry a highly parallel optical screening method for discovery of better electrocatalysts. Science 1998 280 1735-7. Reprinted with permission from AAAS.)...

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