Combinatorial chemistry template

Ralph, J. Brunow, G. Harris, P. J. Dixon, R. A. Schatz, P F. Boerjan, W. Lignification Are lignins biosynthesized via simple combinatorial chemistry or via proteinaceous control and template replication In Advances in Polyphenols Research Daayf, F. El Hadrami, A. Adam, L. Ballance, G. M.,Eds. Blackwell Publishing Oxford, UK, 2008, pp. 36-66. 

Dynamic combinatorial chemistry has recently been used to investigate the process of templating nucleic acid library members to form interesting structures. To date, the templating process has included the development... 

Of particular interest to combinatorial chemistry is the use of immobilised functionalised boronic acid templates which are capable of further transformations [20]. For instance, an aryl carboxylic acid 50 can be converted into the corresponding amide 51 (Scheme 12), whilst still being attached to the resin. Benzyl amine and butylamine were coupled efficiently to afford (after cleavage) the corresponding amides 52 in high yield (Scheme 12). 

Several examples have appeared in the literature in which this linker has been employed in combinatorial chemistry strategies. Thus, it has been used in a Pd-mediated three-component coupling strategy for the solid-phase synthesis of tropane derivatives [46], in the solid-phase synthesis of aspartic acid protease inhibitors [47], in the attachment of cholic acid as a template for a combinatorial approach [48] and, more recently, in the solid-phase synthesis of pyrrolidines via 2-aza allyl anion cycloadditions with alkenes [49]. 

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