Combinatorial chemistry growing accessibility

Palladium-catalyzed transformations greatly enhance the scope of solid-phase synthetic chemistry. A number of fundamental pharmacophores are accessible through a variety of reliable manipulations that may be performed in high yield under mild conditions. This area continues to grow, as solution-phase chemistry is adapted to provide better methods for carbon-carbon bond formation in combinatorial chemistry. We view these advances as central to the field and look forward to future developments. 

It is worth mentioning that the ever-growing interest in the development of novel multicomponent procedures was and is closely related to the needs of combinatorial chemistry (Refs [4, 7-9] and Chapter 16 in this book). Combinatorial compound libraries still play an important role in drug discovery and are commonly composed of 10 to 10 of closely related compounds. Their high exploratory power and simple experimental set-up make MCRs convenient tools for easy and rapid access to such large libraries of organic compounds. 

---