Combinatorial chemistry encoding methods

A W. Czamik, Encoding Methods for Combinatorial Chemistry , Cun. Opin. Chem Biol 1997, X 60-66. 

Nestler, H. P Bartlett, P. A., Still, W. C. A General Method for Molecular Tagging of Encoded Combinatorial Chemistry Libraries. J. Org. Chem. 1994, 59, 4723-4724. 

Much of the early work in combinatorial chemistry focused on the preparation of large mixtures of compounds. The most widely used technique for mixture synthesis is the split/recombine method which assures that each component of the mixture is present in approximately equimolar concentrations. The structures of the bound ligands are determined either through an iterative, or reclusive, deconvolution strategy or through the use of encoded libraries. 

Nielsen J, Brenner S, Janda KD, Synthetic methods for the implementation of encoded combinatorial chemistry, J. Am. Chem. Soc., 115 9812-9813, 1993. 

This review will cover encoding techniques for small organic molecule pool libraries, one of the most challenging and powerful techniques in combinatorial chemistry. A short introduction to illustrate briefly the advantages in library encoding and to compare the method with other structure determination techniques will be given, but for a more detailed introduction the reader should look elsewhere in this book [1]. 

This subject will not be extensively covered in this review because peptide combinatorial chemistry is fully treated elsewhere in this book [13]. Only a few important contributions will be mentioned Nikolaiev et al. [14] reported a general method for peptide encoding of nonsequenceable polymers using... 

Nestler HP, Bartlett PA, Still WC, A general method for molecular tagging of encoded combinatorial chemistry libraries, J. Org. Chem., 59 4723 4724, 1994. 

For a review of current encoding technologies in use for combinatorial chemistry see AW Czamik. New combinatorial methods—encoding. Curr Op Chem Biol 1 60-66, 1997. 

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