Collagen polymer interactions

A. Sionkowska, J. Skopinska-Wisniewska, and M. Wisniewski, Collagen-synthetic polymer interactions in solution cuid in thin films, J. Mol. Liq., 145 (3), 135-138, 2009. 

M. H. Miller and H. A. Scheraga,/. Polym. Sci. Polym. Symp., No. 54,171 (1976). Calculation of the Structures of Collagen Models. Role of Interchain Interactions in Determining the Triple-Helical Coiled-Coil Conformation. I. Poly(glycyl-prolyl-prolyl). 

It is commonly accepted that without the PG/HA interaction, the PGs would not be retained within cartilage. Since the prime task of the negatively charged polymers of the proteoglycans is the binding of water, absence of HA would result in a loss of water and subsequently in a loss of the mechanical properties of cartilage [65]. The interaction with collagen is, however, primarily mediated by the keratan and chondroitin sulfate of the individual PGs. 

Under these conditions, the lifespan of the hyaluronic acid is shortened and filler injections with sensitive polymers should be given some time after a peel. This technique also means an extra journey and more lost time for the patient. 1 have therefore also used Easy TCA at the same time as injections of collagen and different reticulated hyaluronic acids (Restylane , Juvederm , EstMlis , etc.) and have not seen any difference in the behavior of wrinkles, whether or not these injections are combined with Easy TCA . The filler injection is given first and Easy TCA (solution plus post-peel mask) is applied immediately afterwards. The antioxidant qualities of the postpeel mask seem to explain the fact that there is no interaction. 

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