Collagen model

Heidemann, E. and Roth, W. Synthesis and Investigation of Collagen Model Peptides. Vol. 43, pp. 145-205. 

Collagen-Model Peptides with Antiparallel Structure. 177... 

Table 2. Survey of synthesized collagen models. Average molecular weights (M)... 

Table 2 shows a list of collagen model peptides which have teen prepared. Many efforts have been made to prevent racemization. The polycondensation reaction seemed to be more sensitive to racemization than the coupling steps preparing the monomeric tripeptide. Therefore, the sequence of the monomer was selected with Gly or Pro at the C-terminal chain end, because racemization is mostly favored at the carboxy-activated amino acid, and these amino acids cannot racemize. 

Table 8. Thermodynamic parameters of the coil-to-helix transition of collagen-model peptides, covalently linked with 1,2,3-propanetricarboxylic acid (PTC) and Lys-Lys, respectively. Solvent 1% aqueous acetic arid (pH 3.0)...

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