Collagen in diabetes

Monnier VM, Kohn RR and Cerami A (1984) Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci USA 81, 583-587. 

D.G. Dyer, J.A. Dunn, S.R. Thorpe, K.E. Bailie, TJ. Lyons, D.R. McCance, and J.W. Baynes, Accumulation of Maillard reaction products in skin collagen in diabetes and aging, J. Clin. Invest., 1993, 91, 2463-2469. 

H2. Hamlin, C. R., Kohn, R. R., and Luschin, J. H., Apparent accelerated aging ofhuman collagen in diabetes mellitus. Diabetes 24, 902-904 (1975). 

J. R., The efiFect of salicylates on nonenzymatic glycosylation and thermal stability of collagen in diabetic rats. Diabetes 33, 745-751 (1984). 

Sajithlal, G.B., Chithra, P., and Chandrahasan, G. 1998. Effect of curcumin on the advanced glyca-tion and cross-linking of collagen in diabetic rats. BiochemFharmacol. 56 1607-1614. 

Eluorescence of both collagen (Monnier etal., 1986) and IgG (Jones etal., 1988) are associated with diabetic micrOangiopathy. Monnier etal. (1986) found that measured collagen-linked fluorescence in skin biopsies from both patients with type 1 diabetes ( = 41, age range 29-52 years) and controls ( =25, age range 28-41 years) was significantly correlated with the severity of retinopathy as well as arterial and joint stifihess. Jones et al. (1988) found increased fluorescence of serum IgG in diabetic patients with... 

Continuous infusion of transforming growth factor- 3 (TGF- 3) AS-ODN in diabetic mice, decreased kidney TGF- 3 levels and attenuated the increase in kidney weight, and decreased levels of al(IV)collagen and fibronectin mRNAs. 

A higher number of collagen fragments were identified in diabetic patients... 

Diosmin, the 7-rutinoside of diosmetin, 3, 5,7-trihydroxy-4 -methoxyflavone, has been shown to decrease the formation of glycated collagen and haemoglobin in diabetic rats, as well as decreasing the formation of malondialdehyde.612... 

Glomerular lesions, such as those found in diabetes and glomerular nephritis, are characterized by basement membrane thickening and an increase in collagen-like substances within the mesangial regions that ultimately lead to proteinuria. Protease inhibitors prevent thickening of the basement membrane and reduce proteinuria. 

W9. Wells-Knecht, M. C., Lyons, T. J., McCance, D. R., Thorpe, S. R., and Baynes, J. W., Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes. Evidence against a generalized increase in oxidative stress in diabetes. J. Clin. Invest. 100, 839-846 (1997). 

Reiser KM (1991) Nonezymatic glycation of collagen in aging and diabetes. Proc Soc Exp Biol Med 196 17-29. 

Park IS, Kiyomoto H, Abboud SL, Abboud HE. Expression of transforming growth factor-beta and type IV collagen in early streptozotocin-induced diabetes. Diabetes 1997 46 473-80. 

Basement membrane thickening plays a key role in the pathogenesis of diabetic nephropathy. Extra renal sites such as the retina, peripheral nerves, and skeletal muscle capillaries may be involved. The normal basement membrane is made up of collagen-like glycoproteins with the carbohydrate subunits linked to hydro-xylysine and asparagine residues. The increased blood glucose in diabetics perhaps results in increased enzymatic incorporation of carbohydrates into the basement membrane. A reduction in cross-linked cystine residues may render these basement membranes leakier than normal. It is known that diabetic capillaries leak plasma proteins excessively and the size of the leak is dependent on both the duration and success of diabetic control. 

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