Collagen fibriles

Scurvy results from a dietary vitamin C deficiency and involves the inability to form collagen fibrils properly. This is the result of reduced activity of prolyl hydroxylase, which is vitamin C-dependent, as previously noted. Scurvy leads to lesions in the skin and blood vessels, and, in its advanced stages, it can lead to grotesque disfiguration and eventual death. Although rare in the modern world, it was a disease well known to sea-faring explorers in earlier times who did not appreciate the importance of fresh fruits and vegetables in the diet. 

Mineral dust-induced ROMs contributes to pulmonary fibrosis, malignancy, hypersensitivity and emphysema (Doelman etctl., 1990 Kamp etui., 1992). The involvement of ROMs in pulmonary fibrotic reactions is indicated by the participation of PMN oxidants in the autoactivation of latent coUagenase (Weiss et al., 1985). Prolyl hydroxylase, a key enzyme in collagen fibril formation, has been shown to be dependent on the reaction of superoxide with prolyl residues (Myllyla et al., 1979). 

Morimoto K, Kawabata K, Kunii S, Hamano K, Saito T, Tonomura B (2009) Characterization of type I collagen fibril formation using thioflavin T fluorescent dye. J Biochem 145(5) 677... 

Fig. 1.6 (A and B) Scanning electron micro- implantation in the bone marrow showing for-graphs of the porous hydroxyapatite-collagen mation of new bone (white asterisk) attached nanocomposite scaffolds at different magnifi- directly to the nanocomposite (asterisk). Arrows cations. Arrowheads in B indicate the hydroxy- indicate cuboidal osteoblasts on the surface of apatite nanocrystals on the collagen fibrils. new bone. Adapted from [94], reproduced by Histology at (C) 1 week and (D) 4 weeks after permission of Wiley-VCH.

The extracellular space between peripheral nerve fibers is occupied by bundles of collagen fibrils, blood vessels and endoneurial cells 18... 

Chapman, J. A., Tzaphlidou, M., Meek, K. M., and Kadler, K. E. (1990). The collagen fibril—a model system for studying the staining and fixation of a protein. Electron... 

Collagen fibril-associated small proteoglycans of mammalian origin, structure of, 49, 239-261... 

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