Colipase lipid digestion

It is dear that the interconnection between the activities of the different lipolytic enzymes, where the first enzyme modifies the physicochemical state of the lipid substrate in such a way that it becomes available to another enzyme, is not only of prime importance for lipid digestion, but also results in a broad synergism between gastric lipase, colipase, pancreatic lipase, phospholipase As. calcium, caiboxylester Lipase, bite salts, and substrate interraecK tes [55,62-64]. 

Pancreatic lipase, with the aid of colipase, digests the triacylglycerols to 2-monoacylglycerols and free fatty acids, which are packaged into micelles. The micelles, which are tiny microdroplets emulsified by bile salts, also contain other dietary lipids such as cholesterol and the fat-soluble vitamins. 

What is the function of colipase in the digestion of dietary lipids ... 

The encapsulation of chitosan nanoparticles within liposomes and niosomes for its protection from low pH gastric medium was achieved by our group (Jain et al. 2006). It was hypothesized that though phospholipids or surfactants in vesicular form are thought to be unstable in the gastrointestinal environment, it has been reported that gastric lipases do not hydrolyze phospholipids or lipoidal surfactants. The digestion of these lipids takes place mainly in the small intestine by pancreatic lipase, colipase, phospholipase A2 and cholesterol esterase and by the action of bile salts. Thus, vesicular systems apparently provide protection to chitosan nanoparticles in the stomach, while in the intestine, the particles may get or remain encapsulated sequestered and taken by M-cells of the Peyer s patches due to their size as well as bioadhesive nature. 

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