Cognition enhancing drugs

Richards, P.G., Johnson, M.K., Ray, D.E. (2000). Identification of acylpeptide hydrolase as a sensitive site for reaction with organophosphorus compounds and a potential target for cognitive enhancing drugs. Mol. Pharmacol. 58 577-83. 

Devan B, Duffy K, Bowker J et al (2005) Phosphodiesterase type 5 (PDE5) inhibition and cognitive enhancement. Drugs Future 30 725... 

Merlini L, Pinza M (1989) Trends in searching for new cognition enhancing drugs. Prog Neuropsychopharmacol Biol Psychiatry 13 S61-S75... 

Table 6. Marketed Drugs Used as Cognition Enhancers...

Riedel, W. and Jolles, J., Cognition enhancers in age related cognitive decline. Drugs Aging, 8(4), 245-474, 1996. 

Drug discrimination is also an imporfanf sfandard technique used in assessments of the abuse liability of novel psychoactive compounds, with relevance to attempts to develop novel nicotinic agonists for use as cognitive enhancers. 

Many, and quite differentiated, drug effects can be shown and quantified in healthy volunteers under standardized and thus reproducible conditions. The information gathered in these experiments can be usefully applied in a number of theoretical and practical contexts. This chapter has not dealt with some of the herbal medicines, and we also omitted discussion of older studies with simultaneous or consecutive administration of more than one drug, e.g. the so-called scopolamine model to study cognition enhancers (see Spiegel, 1989, p. 180). As will be noted in Chapter 5, experiments in healthy volunteers still play their role in the development of new drugs, some of them under the new name of proof of concept (PoC) or proof of effect (PoE) studies. 

Discovery and use of antidepressants, anxiolytics, antipsychotics, and cognitive enhancers as well as drugs of abuse... 

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