Coffea arabica Nicotiana tabacum

The isoquinoline pathway s enzyme orthologs in other plants showed that genes of methyltransferase family such as (R,S)-reticuline 7-0-methyltransferase, coclaurine 4 -0-methyltransferase, (S)-norcoclaurine 6-0-methyltrasferase, columbamine 0-methyltransferase, coclaurine A-methyltransferase, putrescine A-methyltransferase responsible for the production of reticuline, coclaurine, norcoclaurine, columbaine have been reported from Papaver somniferum, Coptis japonica, Thalictrum flavum, Thalictrum tuberosum, Coffea liberica, Cojfea arabica, Cojfea canephora, Nicotiana tabacum. Solarium tuberosum. Datura stramonium, Hyoscyamus niger, and Atropa belladonna. Pathway contains information of about four alkaloids such as dopamine, colchicine, ephedrine, and methamphetamine and identified two missing links. 

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